Neutralization mechanism of a highly potent antibody against Zika virus
There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the cell, suggesting it might be effective in treating...
Main Authors: | Shuijun Zhang, Victor A. Kostyuchenko, Thiam-Seng Ng, Xin-Ni Lim, Justin S. G. Ooi, Sebastian Lambert, Ter Yong Tan, Douglas G. Widman, Jian Shi, Ralph S. Baric, Shee-Mei Lok |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-11-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms13679 |
Similar Items
-
A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms
by: Shuijun Zhang, et al.
Published: (2020-04-01) -
Capsid protein structure in Zika virus reveals the flavivirus assembly process
by: Ter Yong Tan, et al.
Published: (2020-02-01) -
Abstract OR-9: Cryo-Electron Microscopy Studies of Flaviviruses
by: Victor A. Kostyuchenko, et al.
Published: (2019-06-01) -
Antibody affinity versus dengue morphology influences neutralization.
by: Guntur Fibriansah, et al.
Published: (2021-02-01) -
Role of Zika Virus Envelope Protein Domain III as a Target of Human Neutralizing Antibodies
by: Emily N. Gallichotte, et al.
Published: (2019-09-01)