Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum
Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated...
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doaj-b4268a9d3c774080ae11cfe2e5d4a1382020-11-24T23:23:02ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/361212361212Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral DiverticulumAlireza Zarineh0Elena Bulakhtina1Peter R. Olson2Jan F. Silverman3Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Drexel University College of Medicine, 320 East North Avenue, Pittsburgh, PA 15212, USADepartment of Pathology and Laboratory Medicine, Allegheny General Hospital, Drexel University College of Medicine, 320 East North Avenue, Pittsburgh, PA 15212, USADepartment of Pathology and Laboratory Medicine, Allegheny General Hospital, Drexel University College of Medicine, 320 East North Avenue, Pittsburgh, PA 15212, USADepartment of Pathology and Laboratory Medicine, Allegheny General Hospital, Drexel University College of Medicine, 320 East North Avenue, Pittsburgh, PA 15212, USAVillous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum. A 75-year-old African-American female presented with urethral prolapse complaining of mild voiding difficulty, stress incontinence, and mild spotting of blood. Histological examination revealed a papillary lesion with finger-like processes lined by pseudostratified columnar epithelium with abundant goblet cells. There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia. The lesion recurred at one year without evidence of malignant transformation. We also present a brief literature review of urothelial villous adenomas.http://dx.doi.org/10.1155/2009/361212 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alireza Zarineh Elena Bulakhtina Peter R. Olson Jan F. Silverman |
spellingShingle |
Alireza Zarineh Elena Bulakhtina Peter R. Olson Jan F. Silverman Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum Case Reports in Medicine |
author_facet |
Alireza Zarineh Elena Bulakhtina Peter R. Olson Jan F. Silverman |
author_sort |
Alireza Zarineh |
title |
Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_short |
Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_full |
Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_fullStr |
Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_full_unstemmed |
Recurrent Villous Adenoma with High-Grade Dysplasia Arising in a Urethral Diverticulum |
title_sort |
recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum |
publisher |
Hindawi Limited |
series |
Case Reports in Medicine |
issn |
1687-9627 1687-9635 |
publishDate |
2009-01-01 |
description |
Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations. However, the occurrence of this lesion in the female urethral diverticulum is very unusual. We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum. A 75-year-old African-American female presented with urethral prolapse complaining of mild voiding difficulty, stress incontinence, and mild spotting of blood. Histological examination revealed a papillary lesion with finger-like processes lined by pseudostratified columnar epithelium with abundant goblet cells. There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia. The lesion
recurred at one year without evidence of malignant transformation. We also present a brief literature review of urothelial villous adenomas. |
url |
http://dx.doi.org/10.1155/2009/361212 |
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