Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus
Background: Pyrethroids have been widely used in residential and agricultural areas. However, little is known about the effects of prenatal exposure to deltamethrin on cognition in early development of offspring. In this study, the effects of prenatal exposure to deltamethrin on learning and memory...
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doaj-b4292e24a0614531a81b658745c798012020-11-25T01:47:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-09-011210.3389/fnins.2018.00615409209Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in HippocampusChao Zhang0Chao Zhang1Qinghua Xu2Xia Xiao3Weihao Li4Qiang Kang5Xiong Zhang6Tinghua Wang7Yan Li8Department of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, ChinaDepartment of Pediatrics, Weifang Yidu Central Hospital, Shandong, ChinaDepartment of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, ChinaDepartment of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, ChinaSchool of Stomatology, Kunming Medical University, Kunming, ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, ChinaDepartment of Experimental Zoology, Kunming Medical University, Kunming, ChinaDepartment of Women and Child Health, School of Public Health, Kunming Medical University, Kunming, ChinaBackground: Pyrethroids have been widely used in residential and agricultural areas. However, little is known about the effects of prenatal exposure to deltamethrin on cognition in early development of offspring. In this study, the effects of prenatal exposure to deltamethrin on learning and memory abilities, N-methyl-D-aspartate receptor (NMDAR) subunits, brain derived neurotrophic factor (BDNF), Tyrosine kinase B (TrkB) receptor, and phosphorylated cAMP response element binding protein (pCREB) in the hippocampus of offspring rats were investigated.Experimental Approaches: Groups each of six female SD rats, as F0-generation, were administered with deltamethrin (0, 0.54, 1.35, and 2.7, 9 mg/kg), or memantine (10 mg/kg), or co-administered with deltamethrin (9 mg/kg) and memantine (10 mg/kg) daily by gavage during pregnancy. The learning and memory ability was evaluated using Morris water maze (MWM) task on postnatal day 21. The expression of NMDAR (GluN1, GluN2A, and GluN2B), BDNF, pTrkB/TrkB, and pCREB/CREB in hippocampus were assessed with western blotting.Results: Prenatal exposure to a relatively low dose of deltamethrin (2.7, 1.35, and 0.54 mg/kg) had no impact on learning and memory abilities or the expression of NMDAR, BDNF, pTrkB, and pCREB in the hippocampus of the exposed offspring. The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus. However, the declined cognitive ability were ameliorated by memantine treatment with increased GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB expression in the hippocampus.Conclusion and Implications: Prenatal exposure to a relatively high does of deltamethrin (9 mg/kg) alters cognition in offsprings and that this cognitive dysfunction can be ameliorated by memantine treatment. Moreover, NMDAR/BDNF signaling may be associated with the effects of prenatal exposure to deltamethrin on cognitive ability in offspring.https://www.frontiersin.org/article/10.3389/fnins.2018.00615/fulldeltamethrinN-methyl-D-aspartate receptorcognitive impairmentBDNFCREBTrkB |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chao Zhang Chao Zhang Qinghua Xu Xia Xiao Weihao Li Qiang Kang Xiong Zhang Tinghua Wang Yan Li |
spellingShingle |
Chao Zhang Chao Zhang Qinghua Xu Xia Xiao Weihao Li Qiang Kang Xiong Zhang Tinghua Wang Yan Li Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus Frontiers in Neuroscience deltamethrin N-methyl-D-aspartate receptor cognitive impairment BDNF CREB TrkB |
author_facet |
Chao Zhang Chao Zhang Qinghua Xu Xia Xiao Weihao Li Qiang Kang Xiong Zhang Tinghua Wang Yan Li |
author_sort |
Chao Zhang |
title |
Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus |
title_short |
Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus |
title_full |
Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus |
title_fullStr |
Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus |
title_full_unstemmed |
Prenatal Deltamethrin Exposure-Induced Cognitive Impairment in Offspring Is Ameliorated by Memantine Through NMDAR/BDNF Signaling in Hippocampus |
title_sort |
prenatal deltamethrin exposure-induced cognitive impairment in offspring is ameliorated by memantine through nmdar/bdnf signaling in hippocampus |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2018-09-01 |
description |
Background: Pyrethroids have been widely used in residential and agricultural areas. However, little is known about the effects of prenatal exposure to deltamethrin on cognition in early development of offspring. In this study, the effects of prenatal exposure to deltamethrin on learning and memory abilities, N-methyl-D-aspartate receptor (NMDAR) subunits, brain derived neurotrophic factor (BDNF), Tyrosine kinase B (TrkB) receptor, and phosphorylated cAMP response element binding protein (pCREB) in the hippocampus of offspring rats were investigated.Experimental Approaches: Groups each of six female SD rats, as F0-generation, were administered with deltamethrin (0, 0.54, 1.35, and 2.7, 9 mg/kg), or memantine (10 mg/kg), or co-administered with deltamethrin (9 mg/kg) and memantine (10 mg/kg) daily by gavage during pregnancy. The learning and memory ability was evaluated using Morris water maze (MWM) task on postnatal day 21. The expression of NMDAR (GluN1, GluN2A, and GluN2B), BDNF, pTrkB/TrkB, and pCREB/CREB in hippocampus were assessed with western blotting.Results: Prenatal exposure to a relatively low dose of deltamethrin (2.7, 1.35, and 0.54 mg/kg) had no impact on learning and memory abilities or the expression of NMDAR, BDNF, pTrkB, and pCREB in the hippocampus of the exposed offspring. The group treated with 9 mg/kg deltamethrin showed impaired cognitive abilities and decreased expression levels of GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB in the hippocampus. However, the declined cognitive ability were ameliorated by memantine treatment with increased GluN1, GluN2A, GluN2B, BDNF, pCREB/CREB, and pTrkB/TrkB expression in the hippocampus.Conclusion and Implications: Prenatal exposure to a relatively high does of deltamethrin (9 mg/kg) alters cognition in offsprings and that this cognitive dysfunction can be ameliorated by memantine treatment. Moreover, NMDAR/BDNF signaling may be associated with the effects of prenatal exposure to deltamethrin on cognitive ability in offspring. |
topic |
deltamethrin N-methyl-D-aspartate receptor cognitive impairment BDNF CREB TrkB |
url |
https://www.frontiersin.org/article/10.3389/fnins.2018.00615/full |
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