Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study
<p>Abstract</p> <p>Background</p> <p>Hemispherical asymmetry, sex differences and age-related changes have been reported for the human brain. Meanwhile it was still unclear the presence of the asymmetry or sex differences in the human brain occurred whether as a normal...
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doaj-b42bb294309b41488f2415eca0679a222020-11-25T02:55:58ZengBMCBMC Research Notes1756-05002011-10-014137810.1186/1756-0500-4-378Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based studyFukusumi MasamiTaoka ToshiakiKiuchi KuniakiMorikawa MasayukiKitamura SoichiroKichikawa KimihikoKishimoto Toshifumi<p>Abstract</p> <p>Background</p> <p>Hemispherical asymmetry, sex differences and age-related changes have been reported for the human brain. Meanwhile it was still unclear the presence of the asymmetry or sex differences in the human brain occurred whether as a normal development or as consequences of any pathological changes. The aim of this study was to investigate hemispherical asymmetry, sex differences and age-related changes by using a tract-based analysis in the nerve bundles.</p> <p>Methods</p> <p>40 healthy elderly subjects underwent magnetic resonance diffusion tensor imaging, and we calculated fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the major white matter bundles.</p> <p>Results</p> <p>We identified hemispherical asymmetry in the ADC values for the cingulate fasciculus in the total subject set and in males, and a sex difference in the FA values for the right uncinate fasciculus. For age-related changes, we demonstrated a significant increase in ADC values with advancing age in the right cingulum, left temporal white matter, and a significant decrease in FA values in the right superior longitudinal fasciculus.</p> <p>Conclusion</p> <p>In this study, we found hemispherical asymmetry, sex differences and age-related changes in particular regions of the white matter in the healthy elderly. Our results suggest considering these differences can be important in imaging studies.</p> http://www.biomedcentral.com/1756-0500/4/378diffusion tensor imagingtractographyasymmetrysex differenceagingwhite matter |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fukusumi Masami Taoka Toshiaki Kiuchi Kuniaki Morikawa Masayuki Kitamura Soichiro Kichikawa Kimihiko Kishimoto Toshifumi |
spellingShingle |
Fukusumi Masami Taoka Toshiaki Kiuchi Kuniaki Morikawa Masayuki Kitamura Soichiro Kichikawa Kimihiko Kishimoto Toshifumi Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study BMC Research Notes diffusion tensor imaging tractography asymmetry sex difference aging white matter |
author_facet |
Fukusumi Masami Taoka Toshiaki Kiuchi Kuniaki Morikawa Masayuki Kitamura Soichiro Kichikawa Kimihiko Kishimoto Toshifumi |
author_sort |
Fukusumi Masami |
title |
Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study |
title_short |
Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study |
title_full |
Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study |
title_fullStr |
Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study |
title_full_unstemmed |
Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study |
title_sort |
asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2011-10-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Hemispherical asymmetry, sex differences and age-related changes have been reported for the human brain. Meanwhile it was still unclear the presence of the asymmetry or sex differences in the human brain occurred whether as a normal development or as consequences of any pathological changes. The aim of this study was to investigate hemispherical asymmetry, sex differences and age-related changes by using a tract-based analysis in the nerve bundles.</p> <p>Methods</p> <p>40 healthy elderly subjects underwent magnetic resonance diffusion tensor imaging, and we calculated fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the major white matter bundles.</p> <p>Results</p> <p>We identified hemispherical asymmetry in the ADC values for the cingulate fasciculus in the total subject set and in males, and a sex difference in the FA values for the right uncinate fasciculus. For age-related changes, we demonstrated a significant increase in ADC values with advancing age in the right cingulum, left temporal white matter, and a significant decrease in FA values in the right superior longitudinal fasciculus.</p> <p>Conclusion</p> <p>In this study, we found hemispherical asymmetry, sex differences and age-related changes in particular regions of the white matter in the healthy elderly. Our results suggest considering these differences can be important in imaging studies.</p> |
topic |
diffusion tensor imaging tractography asymmetry sex difference aging white matter |
url |
http://www.biomedcentral.com/1756-0500/4/378 |
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