Cellulose/chondroitin sulphate hydrogels as carriers for drug delivery applications
The potential of the hydrogels based on natural, biodegradable and biocompatible polysaccharides, cellulose (C) and chondrotin sulphate (GAG), as sustained release vehicles, has been followed by in vitro swelling and drug release studies. The swelling studies were performed by mass measurements at 3...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
"Alexandru Ioan Cuza" University of Iași
2009-09-01
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| Series: | Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
| Online Access: | http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/537 |
| Summary: | The potential of the hydrogels based on natural, biodegradable and biocompatible polysaccharides, cellulose
(C) and chondrotin sulphate (GAG), as sustained release vehicles, has been followed by in vitro swelling and drug release
studies. The swelling studies were performed by mass measurements at 37 0C in twice distilled water. The release profiles
and release kinetics of codeine, an opiate used for its analgesic, antitussive and antidiarrheal properties, were determined.
Water-uptake data and drug release measurements are given for characterization of new solid dosage forms, the
importance of the chondroitin sulphate presence being also discussed. The biocompatibility testing was made by
hemolysis (plasma hemoglobin) technique. It seems that cellulose/chondroitin sulphate hydrogels are promising
formulations for drug delivery. |
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| ISSN: | 1582-3571 2248-3276 |