‘Capiture’ plants with interesting biological activities: a case to go
The investigation of natural products used in Traditional Medicine in Africa is complicated as modern analytical and screening methods are often not available. Computer aided product identification from traditional usage records (CAPITURE) may provide an interesting alternative and has been evaluate...
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doaj-b437c227344d4cfca9aa5d37004595ed2021-09-06T19:19:34ZengDe GruyterOpen Chemistry2391-54202017-10-0115120821810.1515/chem-2017-0024chem-2017-0024‘Capiture’ plants with interesting biological activities: a case to goTittikpina Nassifatou Koko0Atakpama Wouyo1Pereki Hodabalo2Nasim Muhammad Jawad3Ali Wesam4Fontanay Stéphane5Nana Frédéric6Ejike Chukwunonso Ecc7Kirsch Gilbert8Duval Raphaël Emmanuel9Chaimbault Patrick10Karou Simplice D.11Batawila Komlan12Akpagana Koffi13Jacob Claus14Faculty of Pharmacy, Department of Bio-organic Chemistry, Building B 2.1., Room 1.13. Saarland State University, Campus D-66123Saarbrücken, GermanyLaboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, TogoLaboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, TogoSchool of Pharmacy, Division of Bioorganic Chemistry, Building B 2.1., Room 1.13. University of Saarland, Campus D-66123Saarbrücken, GermanySchool of Pharmacy, Division of Bioorganic Chemistry, Building B 2.1., Room 1.13. University of Saarland, Campus D-66123Saarbrücken, GermanyCNRS, UMR 7565, SRSMC, Vandoeuvre-lès-Nancy, F-54506Nancy, FranceUniversité de Lorraine, SRSMC, UMR 7565, 54001NANCY Cedex. FranceDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University Ndufu-Alike, Ikwo, PMB 1010Abakaliki, Ebonyi State, NigeriaUniversité de Lorraine, SRSMC, UMR 7565, 54001NANCY Cedex. FranceCNRS, UMR 7565, SRSMC, Vandoeuvre-lès-Nancy, F-54506Nancy, FranceUniversité de Lorraine, SRSMC, UMR 7565, 54001NANCY Cedex. FranceEcole Supérieure des Techniques Biologiques et Alimentaires (ESTBA-UL), Université de Lomé, Lomé, TogoLaboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, TogoLaboratoire de Botanique et Ecologie Végétale, Université de Lomé, BP 1515, Lomé, TogoSchool of Pharmacy, Division of Bioorganic Chemistry, Building B 2.1., Room 1.13. University of Saarland, Campus D-66123Saarbrücken, GermanyThe investigation of natural products used in Traditional Medicine in Africa is complicated as modern analytical and screening methods are often not available. Computer aided product identification from traditional usage records (CAPITURE) may provide an interesting alternative and has been evaluated in the context of an ethnobotanical survey on fungal diseases and their traditional treatment in Tchamba District (Togo). 53 traditional healers were interviewed and their knowledge recorded. Several indicators, the Use Value (UV), Plant Part Value (PPV), Specific Use (SU) Value, Intraspecific Use Value (IUV) and Informant Consensus Factor (ICF), were applied to the data. Those indices, in addition to a bibliographic review, were then fed into a computer-aided approach which predicted two interesting plants out of the 43 species survey-recorded and their specific activities: Pterocarpus erinaceus sap against ringworm, Daniellia oliveri sap against intertrigo and respectively their roots and trunk barks against candidiasis. Subsequent laboratory-based studies have confirmed the predicted antimicrobial activities with MIC (128 μg/mL to 30 mg/mL) and without any notable toxicity on a normal human cell (MRC-5 cells). Although such a method may not be flawless, it is able to provide first leads, and in the face of limited resources, is an attractive alternative worth considering.https://doi.org/10.1515/chem-2017-0024computer-assisted selectionethnobotanyfungal diseasestchambatogo |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tittikpina Nassifatou Koko Atakpama Wouyo Pereki Hodabalo Nasim Muhammad Jawad Ali Wesam Fontanay Stéphane Nana Frédéric Ejike Chukwunonso Ecc Kirsch Gilbert Duval Raphaël Emmanuel Chaimbault Patrick Karou Simplice D. Batawila Komlan Akpagana Koffi Jacob Claus |
spellingShingle |
Tittikpina Nassifatou Koko Atakpama Wouyo Pereki Hodabalo Nasim Muhammad Jawad Ali Wesam Fontanay Stéphane Nana Frédéric Ejike Chukwunonso Ecc Kirsch Gilbert Duval Raphaël Emmanuel Chaimbault Patrick Karou Simplice D. Batawila Komlan Akpagana Koffi Jacob Claus ‘Capiture’ plants with interesting biological activities: a case to go Open Chemistry computer-assisted selection ethnobotany fungal diseases tchamba togo |
author_facet |
Tittikpina Nassifatou Koko Atakpama Wouyo Pereki Hodabalo Nasim Muhammad Jawad Ali Wesam Fontanay Stéphane Nana Frédéric Ejike Chukwunonso Ecc Kirsch Gilbert Duval Raphaël Emmanuel Chaimbault Patrick Karou Simplice D. Batawila Komlan Akpagana Koffi Jacob Claus |
author_sort |
Tittikpina Nassifatou Koko |
title |
‘Capiture’ plants with interesting biological activities: a case to go |
title_short |
‘Capiture’ plants with interesting biological activities: a case to go |
title_full |
‘Capiture’ plants with interesting biological activities: a case to go |
title_fullStr |
‘Capiture’ plants with interesting biological activities: a case to go |
title_full_unstemmed |
‘Capiture’ plants with interesting biological activities: a case to go |
title_sort |
‘capiture’ plants with interesting biological activities: a case to go |
publisher |
De Gruyter |
series |
Open Chemistry |
issn |
2391-5420 |
publishDate |
2017-10-01 |
description |
The investigation of natural products used in Traditional Medicine in Africa is complicated as modern analytical and screening methods are often not available. Computer aided product identification from traditional usage records (CAPITURE) may provide an interesting alternative and has been evaluated in the context of an ethnobotanical survey on fungal diseases and their traditional treatment in Tchamba District (Togo). 53 traditional healers were interviewed and their knowledge recorded. Several indicators, the Use Value (UV), Plant Part Value (PPV), Specific Use (SU) Value, Intraspecific Use Value (IUV) and Informant Consensus Factor (ICF), were applied to the data. Those indices, in addition to a bibliographic review, were then fed into a computer-aided approach which predicted two interesting plants out of the 43 species survey-recorded and their specific activities: Pterocarpus erinaceus sap against ringworm, Daniellia oliveri sap against intertrigo and respectively their roots and trunk barks against candidiasis. Subsequent laboratory-based studies have confirmed the predicted antimicrobial activities with MIC (128 μg/mL to 30 mg/mL) and without any notable toxicity on a normal human cell (MRC-5 cells). Although such a method may not be flawless, it is able to provide first leads, and in the face of limited resources, is an attractive alternative worth considering. |
topic |
computer-assisted selection ethnobotany fungal diseases tchamba togo |
url |
https://doi.org/10.1515/chem-2017-0024 |
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