Mitochondrial Quality Control in COPD and IPF
Mitochondria play important roles in the maintenance of intracellular homeostasis; hence, the quality control of mitochondria is crucial for cell fate determination. Mitochondria dynamics and mitochondria-specific autophagy, known as mitophagy, are two main quality control systems in cells. Mitochon...
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doaj-b445fd55b00b4fd3a5fa212cba94cd892020-11-24T23:11:07ZengMDPI AGCells2073-44092018-07-01788610.3390/cells7080086cells7080086Mitochondrial Quality Control in COPD and IPFHiromichi Hara0Kazuyoshi Kuwano1Jun Araya2Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, JapanDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, JapanDivision of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, JapanMitochondria play important roles in the maintenance of intracellular homeostasis; hence, the quality control of mitochondria is crucial for cell fate determination. Mitochondria dynamics and mitochondria-specific autophagy, known as mitophagy, are two main quality control systems in cells. Mitochondria fuse to increase energy production in response to stress, and damaged mitochondria are segregated by fission and degraded by mitophagy. Once these systems are disrupted, dysfunctional mitochondria with decreased adenosine triphosphate (ATP) production and increased reactive oxygen species (ROS) production accumulate, affecting cell fate. Recently, increasing evidence suggests that the dysregulation of mitochondria quality control is pathogenic in several age-related diseases. In this review, we outlined the role of mitochondria quality control systems in the pathogenesis of age-associated lung diseases, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).http://www.mdpi.com/2073-4409/7/8/86mitochondriamitochondria dynamicsmitophagychronic obstructive pulmonary disease (COPD)idiopathic pulmonary fibrosis (IPF) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiromichi Hara Kazuyoshi Kuwano Jun Araya |
spellingShingle |
Hiromichi Hara Kazuyoshi Kuwano Jun Araya Mitochondrial Quality Control in COPD and IPF Cells mitochondria mitochondria dynamics mitophagy chronic obstructive pulmonary disease (COPD) idiopathic pulmonary fibrosis (IPF) |
author_facet |
Hiromichi Hara Kazuyoshi Kuwano Jun Araya |
author_sort |
Hiromichi Hara |
title |
Mitochondrial Quality Control in COPD and IPF |
title_short |
Mitochondrial Quality Control in COPD and IPF |
title_full |
Mitochondrial Quality Control in COPD and IPF |
title_fullStr |
Mitochondrial Quality Control in COPD and IPF |
title_full_unstemmed |
Mitochondrial Quality Control in COPD and IPF |
title_sort |
mitochondrial quality control in copd and ipf |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2018-07-01 |
description |
Mitochondria play important roles in the maintenance of intracellular homeostasis; hence, the quality control of mitochondria is crucial for cell fate determination. Mitochondria dynamics and mitochondria-specific autophagy, known as mitophagy, are two main quality control systems in cells. Mitochondria fuse to increase energy production in response to stress, and damaged mitochondria are segregated by fission and degraded by mitophagy. Once these systems are disrupted, dysfunctional mitochondria with decreased adenosine triphosphate (ATP) production and increased reactive oxygen species (ROS) production accumulate, affecting cell fate. Recently, increasing evidence suggests that the dysregulation of mitochondria quality control is pathogenic in several age-related diseases. In this review, we outlined the role of mitochondria quality control systems in the pathogenesis of age-associated lung diseases, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). |
topic |
mitochondria mitochondria dynamics mitophagy chronic obstructive pulmonary disease (COPD) idiopathic pulmonary fibrosis (IPF) |
url |
http://www.mdpi.com/2073-4409/7/8/86 |
work_keys_str_mv |
AT hiromichihara mitochondrialqualitycontrolincopdandipf AT kazuyoshikuwano mitochondrialqualitycontrolincopdandipf AT junaraya mitochondrialqualitycontrolincopdandipf |
_version_ |
1725605630275747840 |