Mitochondrial Quality Control in COPD and IPF

• Main Authors: Hiromichi Hara, Kazuyoshi Kuwano, Jun Araya
• Format: Article
• Language: English
• Published: MDPI AG 2018-07-01
• Series: Cells
• Subjects: mitochondria; mitochondria dynamics; mitophagy; chronic obstructive pulmonary disease (COPD); idiopathic pulmonary fibrosis (IPF)
• Online Access: http://www.mdpi.com/2073-4409/7/8/86

Mitochondria play important roles in the maintenance of intracellular homeostasis; hence, the quality control of mitochondria is crucial for cell fate determination. Mitochondria dynamics and mitochondria-specific autophagy, known as mitophagy, are two main quality control systems in cells. Mitochondria fuse to increase energy production in response to stress, and damaged mitochondria are segregated by fission and degraded by mitophagy. Once these systems are disrupted, dysfunctional mitochondria with decreased adenosine triphosphate (ATP) production and increased reactive oxygen species (ROS) production accumulate, affecting cell fate. Recently, increasing evidence suggests that the dysregulation of mitochondria quality control is pathogenic in several age-related diseases. In this review, we outlined the role of mitochondria quality control systems in the pathogenesis of age-associated lung diseases, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF).