Transgenic Rabbits Expressing Ovine PrP Are Susceptible to Scrapie.
Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases affecting a wide range of mammalian species. They are caused by prions, a proteinaceous pathogen essentially composed of PrPSc, an abnormal isoform of the host encoded cellular prion protein PrPC. Constrained...
Main Authors: | Pierre Sarradin, Céline Viglietta, Claude Limouzin, Olivier Andréoletti, Nathalie Daniel-Carlier, Céline Barc, Mathieu Leroux-Coyau, Patricia Berthon, Jérôme Chapuis, Christelle Rossignol, Jean-Luc Gatti, Maya Belghazi, Valérie Labas, Jean-Luc Vilotte, Vincent Béringue, Frédéric Lantier, Hubert Laude, Louis-Marie Houdebine |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-08-01
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Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1005077 |
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