Sex, gut microbiome, and cardiovascular disease risk
Abstract Key differences exist between men and women in the determinants and manifestations of cardiovascular and cardiometabolic diseases. Recently, gut microbiome-host relations have been implicated in cardiovascular disease and associated metabolic conditions; therefore, gut microbiota may be key...
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doaj-b45824ea36e448708230808c202c05dc2020-11-25T02:23:51ZengBMCBiology of Sex Differences2042-64102019-06-0110111410.1186/s13293-019-0240-zSex, gut microbiome, and cardiovascular disease riskAlexander C. Razavi0Kaitlin S. Potts1Tanika N. Kelly2Lydia A. Bazzano3Department of Medicine, Tulane University School of MedicineDepartment of Epidemiology, Tulane University School of Public Health and Tropical MedicineDepartment of Epidemiology, Tulane University School of Public Health and Tropical MedicineDepartment of Medicine, Tulane University School of MedicineAbstract Key differences exist between men and women in the determinants and manifestations of cardiovascular and cardiometabolic diseases. Recently, gut microbiome-host relations have been implicated in cardiovascular disease and associated metabolic conditions; therefore, gut microbiota may be key mediators or modulators driving the observed sexual dimorphism in disease onset and progression. While current evidence regarding pure physiological sex differences in gut microbiome composition is modest, robust research suggests that gut microbiome-dependent metabolites may interact with important biological pathways under sex hormone control, including toll-like receptor and flavin monooxygenase signaling. Here, we review key sex differences in gut microbiome interactions with four primary determinants of cardiovascular disease, impaired glucose regulation, dyslipidemia, hypertension, and obesity. Through this process, we propose important sex differences in downstream metabolic pathways that may be at the interface of the gut microbiome and cardiovascular disease.http://link.springer.com/article/10.1186/s13293-019-0240-zGut microbiomeCardiovascular diseasesSex differenceObesityLipidsInsulin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexander C. Razavi Kaitlin S. Potts Tanika N. Kelly Lydia A. Bazzano |
spellingShingle |
Alexander C. Razavi Kaitlin S. Potts Tanika N. Kelly Lydia A. Bazzano Sex, gut microbiome, and cardiovascular disease risk Biology of Sex Differences Gut microbiome Cardiovascular diseases Sex difference Obesity Lipids Insulin |
author_facet |
Alexander C. Razavi Kaitlin S. Potts Tanika N. Kelly Lydia A. Bazzano |
author_sort |
Alexander C. Razavi |
title |
Sex, gut microbiome, and cardiovascular disease risk |
title_short |
Sex, gut microbiome, and cardiovascular disease risk |
title_full |
Sex, gut microbiome, and cardiovascular disease risk |
title_fullStr |
Sex, gut microbiome, and cardiovascular disease risk |
title_full_unstemmed |
Sex, gut microbiome, and cardiovascular disease risk |
title_sort |
sex, gut microbiome, and cardiovascular disease risk |
publisher |
BMC |
series |
Biology of Sex Differences |
issn |
2042-6410 |
publishDate |
2019-06-01 |
description |
Abstract Key differences exist between men and women in the determinants and manifestations of cardiovascular and cardiometabolic diseases. Recently, gut microbiome-host relations have been implicated in cardiovascular disease and associated metabolic conditions; therefore, gut microbiota may be key mediators or modulators driving the observed sexual dimorphism in disease onset and progression. While current evidence regarding pure physiological sex differences in gut microbiome composition is modest, robust research suggests that gut microbiome-dependent metabolites may interact with important biological pathways under sex hormone control, including toll-like receptor and flavin monooxygenase signaling. Here, we review key sex differences in gut microbiome interactions with four primary determinants of cardiovascular disease, impaired glucose regulation, dyslipidemia, hypertension, and obesity. Through this process, we propose important sex differences in downstream metabolic pathways that may be at the interface of the gut microbiome and cardiovascular disease. |
topic |
Gut microbiome Cardiovascular diseases Sex difference Obesity Lipids Insulin |
url |
http://link.springer.com/article/10.1186/s13293-019-0240-z |
work_keys_str_mv |
AT alexandercrazavi sexgutmicrobiomeandcardiovasculardiseaserisk AT kaitlinspotts sexgutmicrobiomeandcardiovasculardiseaserisk AT tanikankelly sexgutmicrobiomeandcardiovasculardiseaserisk AT lydiaabazzano sexgutmicrobiomeandcardiovasculardiseaserisk |
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