Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats

Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats

Our previous studies showed that administration of a subtoxic dose of acetaminophen (APAP) to female rats increased generation of carbon monoxide from dichloromethane, a metabolic reaction catalyzed mainly by cytochrome P450 (CYP) 2E1. In this study we examined the changes in metabolism and toxicity...

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Bibliographic Details
Main Authors:	Sun J. Kim, Min Y. Lee, Do Y. Kwon, Sung Y. Kim, Young C. Kim
Format:	Article
Language:	English
Published:	Elsevier 2009-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319311168

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