Synthesis and investigation of the derivatives of amidinohydrazonelated aromatic compounds as furin inhibitors

Synthesis and investigation of the derivatives of amidinohydrazonelated aromatic compounds as furin inhibitors

The proprotein convertase furin plays a crucial role in a variety of pathogenic processes such as cancer, bacterial and viral diseases, neurodegenerative disorders and diabetes. Thus, furin inhibitors are promi­sing therapeutics for the treatment of many diseases. In this study we synthesized some n...

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Bibliographic Details
Main Authors: T. V. Osadchuk, A. V. Semyroz, O. V. Shybyryn, V. K. Kibirev
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2017-12-01
Series:Ukrainian Biochemical Journal
Subjects:
amidinohydrazones
furin
furin inhibitors
inhibition mechanism
Online Access:http://ukrbiochemjournal.org/2017/12/synthesis-and-investigation-of-the-derivatives-of-amidinohydrazonelated-aromatic-compounds-as-furin-inhibitors.html

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http://ukrbiochemjournal.org/2017/12/synthesis-and-investigation-of-the-derivatives-of-amidinohydrazonelated-aromatic-compounds-as-furin-inhibitors.html

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