Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis

• Main Authors: Huiyan Wang, Dongying Gu, Miao Yu, Yanjun Hu, Zhe Chen, Xinying Huo, Tao Yu, Jinfei Chen, Yang Zheng
• Format: Article
• Language: English
• Published: BMC 2021-02-01
• Series: BMC Cancer
• Subjects: Colorectal cancer; Adenomas; SNP; rs9929218; Meta-analysis
• Online Access: https://doi.org/10.1186/s12885-021-07871-z

Abstract Backgrounds Genome-wide association studies (GWAS) have identified multiple common CRC-related (colorectal cancer) SNPs (single nucleotide polymorphisms) including the Cadherin 1(CDH1) rs9929218 may act by increasing the risk of colorectal cancer, colorectal adenoma, or both. These studies, however, reported inconsistent associations. Methods To derive a more accurate approximation of the connection, we carried out a meta-analysis of 12 published pieces of research including 11,590 controls and 8192 cases. We used odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the associations’ strength. Results Meta-analysis implied considerable association between CRC and rs9929218 (OR = 1.21, 95%CI 1.04–1.42 for GG versus AA; OR = 1.22, 95%CI 1.05–1.42 for GG/AG versus AA). In the subgroup analyses, significantly increased risks were found among Europeans. Conclusions In summary, our meta-analysis studies in different populations confirmed that SNP rs9929218 is significantly associated with CRC risk and that this variant may have a greater impact on Europeans.