Optimization of the cyclotide framework to improve cell penetration properties

Optimization of the cyclotide framework to improve cell penetration properties

Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic dis...

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Bibliographic Details
Main Authors: Yen-Hua eHuang, Stephanie eChaousis, Olivier eCheneval, David J. Craik, Sonia eTroeira Henriques
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Pharmacology
Subjects:
Cyclotides
Drug delivery
peptide scaffold
Cyclic cell penetrating peptide
peptide reengineering
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00017/full

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