A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population
Considering urinary tract infections (UTIs), a significant public health problem with negligible recent research, especially on the male eastern European population, we aimed to determine the antimicrobial resistance rates of uropathogens for the most commonly used antibiotics in urological practice...
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doaj-b48d1f13ca9d4e2393a7cd83ad8a4f3b2020-11-25T02:27:06ZengMDPI AGMicroorganisms2076-26072020-06-01884884810.3390/microorganisms8060848A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male PopulationCălin Bogdan Chibelean0Răzvan-Cosmin Petca1Cristian Mareș2Răzvan-Ionuț Popescu3Barabás Enikő4Claudia Mehedințu5Aida Petca6George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu-Mures, 38 Gheorghe Marinescu str., 540139 Targu-Mures, Romania“Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari blvd., 050474 Bucharest, RomaniaDepartment of Urology, “Prof. Dr. Th. Burghele” Clinical Hospital, 20 Panduri str., 050659 Bucharest, RomaniaDepartment of Urology, “Prof. Dr. Th. Burghele” Clinical Hospital, 20 Panduri str., 050659 Bucharest, RomaniaGeorge Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu-Mures, 38 Gheorghe Marinescu str., 540139 Targu-Mures, Romania“Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari blvd., 050474 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari blvd., 050474 Bucharest, RomaniaConsidering urinary tract infections (UTIs), a significant public health problem with negligible recent research, especially on the male eastern European population, we aimed to determine the antimicrobial resistance rates of uropathogens for the most commonly used antibiotics in urological practice in our country. We conducted a multicenter retrospective study in two different teaching hospitals in Romania, analyzing urine samples from 7719 patients to determine the frequency of incriminating pathogens and their resistance to different antibiotics, in a comparative approach. We determined <i>Escherichia coli</i> (35.98%) to be the most common pathogen with the highest sensitivity to amikacin (S = 91.72%), meropenem (S = 97.17%) and fosfomycin (S = 86.60%) and important resistance to amoxicillin-clavulanic ac. (R = 28.03%) and levofloxacin (R = 37.69%), followed by <i>Klebsiella</i> spp. (22.98%) with the highest sensitivity to amikacin (S = 78.04%) and meropenem (S = 81.35%) and important resistance to amoxicillin-clavulanic ac. (R = 65.58%) and levofloxacin (R = 45.36%); the most frequent Gram-positive pathogen was <i>Enterococcus</i> spp. (19.73%) with the highest sensitivity for vancomycin (S = 93.75%) and fosfomycin (S = 87.5%) and considerable resistance to penicillin (R = 33.52%) and levofloxacin (R = 42.04%). The findings are an important tool in managing UTIs and should be acknowledged as reference research not only for clinicians from Romania but for all physicians treating male UTIs.https://www.mdpi.com/2076-2607/8/6/848antimicrobial resistanceAMRurinary tract infectionsUTIsuropathogens<i>E. coli</i> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Călin Bogdan Chibelean Răzvan-Cosmin Petca Cristian Mareș Răzvan-Ionuț Popescu Barabás Enikő Claudia Mehedințu Aida Petca |
spellingShingle |
Călin Bogdan Chibelean Răzvan-Cosmin Petca Cristian Mareș Răzvan-Ionuț Popescu Barabás Enikő Claudia Mehedințu Aida Petca A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population Microorganisms antimicrobial resistance AMR urinary tract infections UTIs uropathogens <i>E. coli</i> |
author_facet |
Călin Bogdan Chibelean Răzvan-Cosmin Petca Cristian Mareș Răzvan-Ionuț Popescu Barabás Enikő Claudia Mehedințu Aida Petca |
author_sort |
Călin Bogdan Chibelean |
title |
A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_short |
A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_full |
A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_fullStr |
A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_full_unstemmed |
A Clinical Perspective on the Antimicrobial Resistance Spectrum of Uropathogens in a Romanian Male Population |
title_sort |
clinical perspective on the antimicrobial resistance spectrum of uropathogens in a romanian male population |
publisher |
MDPI AG |
series |
Microorganisms |
issn |
2076-2607 |
publishDate |
2020-06-01 |
description |
Considering urinary tract infections (UTIs), a significant public health problem with negligible recent research, especially on the male eastern European population, we aimed to determine the antimicrobial resistance rates of uropathogens for the most commonly used antibiotics in urological practice in our country. We conducted a multicenter retrospective study in two different teaching hospitals in Romania, analyzing urine samples from 7719 patients to determine the frequency of incriminating pathogens and their resistance to different antibiotics, in a comparative approach. We determined <i>Escherichia coli</i> (35.98%) to be the most common pathogen with the highest sensitivity to amikacin (S = 91.72%), meropenem (S = 97.17%) and fosfomycin (S = 86.60%) and important resistance to amoxicillin-clavulanic ac. (R = 28.03%) and levofloxacin (R = 37.69%), followed by <i>Klebsiella</i> spp. (22.98%) with the highest sensitivity to amikacin (S = 78.04%) and meropenem (S = 81.35%) and important resistance to amoxicillin-clavulanic ac. (R = 65.58%) and levofloxacin (R = 45.36%); the most frequent Gram-positive pathogen was <i>Enterococcus</i> spp. (19.73%) with the highest sensitivity for vancomycin (S = 93.75%) and fosfomycin (S = 87.5%) and considerable resistance to penicillin (R = 33.52%) and levofloxacin (R = 42.04%). The findings are an important tool in managing UTIs and should be acknowledged as reference research not only for clinicians from Romania but for all physicians treating male UTIs. |
topic |
antimicrobial resistance AMR urinary tract infections UTIs uropathogens <i>E. coli</i> |
url |
https://www.mdpi.com/2076-2607/8/6/848 |
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