Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus
<p>Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, which is characterized by high levels of autoantibodies and multisystem damage. Neuropsychiatric SLE (NPSLE) involves both the central and peripheral nervous systems, which is one major cause of death in SLE pat...
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doaj-b497b97aba664bce8782ed0ab72e48152020-11-25T01:22:04ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312014-09-011497697741031Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosusChang-hao XIE0Xiang LIAO1Ling-yun SUN2Guo-min DENG3Department of Microbiology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu, ChinaDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, Jiangsu, China<p>Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, which is characterized by high levels of autoantibodies and multisystem damage. Neuropsychiatric SLE (NPSLE) involves both the central and peripheral nervous systems, which is one major cause of death in SLE patients. Pathogenesis of NPSLE is complicated. Currently it is known that there are two mechanisms to be involved in NPSLE: one is cerebrovascular injury mediated by immune complex containing autoantibodies, and the other is brain tissue damage induced by inflammatory mediators originated from autoimmunity.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.09.006</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1035Lupus vasculitis, central nervous systemAutoantibodiesReview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chang-hao XIE Xiang LIAO Ling-yun SUN Guo-min DENG |
spellingShingle |
Chang-hao XIE Xiang LIAO Ling-yun SUN Guo-min DENG Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus Chinese Journal of Contemporary Neurology and Neurosurgery Lupus vasculitis, central nervous system Autoantibodies Review |
author_facet |
Chang-hao XIE Xiang LIAO Ling-yun SUN Guo-min DENG |
author_sort |
Chang-hao XIE |
title |
Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus |
title_short |
Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus |
title_full |
Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus |
title_fullStr |
Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus |
title_full_unstemmed |
Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus |
title_sort |
autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2014-09-01 |
description |
<p>Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, which is characterized by high levels of autoantibodies and multisystem damage. Neuropsychiatric SLE (NPSLE) involves both the central and peripheral nervous systems, which is one major cause of death in SLE patients. Pathogenesis of NPSLE is complicated. Currently it is known that there are two mechanisms to be involved in NPSLE: one is cerebrovascular injury mediated by immune complex containing autoantibodies, and the other is brain tissue damage induced by inflammatory mediators originated from autoimmunity.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.09.006</p> |
topic |
Lupus vasculitis, central nervous system Autoantibodies Review |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/1035 |
work_keys_str_mv |
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