Autoregulatory control of microtubule binding in doublecortin-like kinase 1

Autoregulatory control of microtubule binding in doublecortin-like kinase 1

The microtubule-associated protein, doublecortin-like kinase 1 (DCLK1), is highly expressed in a range of cancers and is a prominent therapeutic target for kinase inhibitors. The physiological roles of DCLK1 kinase activity and how it is regulated remain elusive. Here, we analyze the role of mammali...

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Bibliographic Details
Main Authors: Regina L Agulto, Melissa M Rogers, Tracy C Tan, Amrita Ramkumar, Ashlyn M Downing, Hannah Bodin, Julia Castro, Dan W Nowakowski, Kassandra M Ori-McKenney
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
autophosphorylation
microtubule-associated protein
doublecortin-like kinase 1
cancer
microtubule
MAP
Online Access:https://elifesciences.org/articles/60126

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