Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice
In the recent years, interest in soybean as a neuroprotective nutrient in the management of Alzheimer’s disease (AD) has increased and soy isoflavones (SI), as kinds of soybean phytochemicals, are thought to be biologically active components that confer this beneficial effect against neuro...
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doaj-b4be29d5264743669cb3d00e73edc6972020-11-25T00:09:03ZengMDPI AGNutrients2072-66432018-06-0110785310.3390/nu10070853nu10070853Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in MiceCong Lu0Yan Wang1Donghui Wang2Lijing Zhang3Jingwei Lv4Ning Jiang5Bei Fan6Xinmin Liu7Fengzhong Wang8Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, ChinaResearch Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100193, ChinaResearch Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100193, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, ChinaResearch Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100193, ChinaInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, ChinaIn the recent years, interest in soybean as a neuroprotective nutrient in the management of Alzheimer’s disease (AD) has increased and soy isoflavones (SI), as kinds of soybean phytochemicals, are thought to be biologically active components that confer this beneficial effect against neurodegenerative diseases. However, the neuroprotective effect of SI is not well understood. Therefore, the present study (30 days) was conducted to investigate the neuroprotective effects of soy isoflavones (SI) on scopolamine (SCOP)-induced memory impairments in Institute of Cancer Research (ICR) mice (aged 4 weeks) and to elucidate its underlying mechanisms of action. SI (40 mg/kg) administration improved the cognitive performance of SCOP-treated mice in an object location recognition task and the Morris water maze test. SI (40 mg/kg) administration significantly enhanced cholinergic system function and suppressed oxidative stress levels in the hippocampus of SCOP-treated mice. Furthermore, SI (40 mg/kg) treatment markedly upregulated the phosphorylation levels of extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus. Taken together, these results demonstrated that soy isoflavones exerted a significant neuroprotective effect on cognitive dysfunctions induced by scopolamine, suggesting that soy isoflavones could be a good candidate for possible treatment of neurodegenerative diseases, such as Alzheimer’s disease (AD).http://www.mdpi.com/2072-6643/10/7/853soy isoflavonesscopolaminelearning and memorycholinergic system functionoxidative stressERK/CREB/BDNF pathway |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cong Lu Yan Wang Donghui Wang Lijing Zhang Jingwei Lv Ning Jiang Bei Fan Xinmin Liu Fengzhong Wang |
spellingShingle |
Cong Lu Yan Wang Donghui Wang Lijing Zhang Jingwei Lv Ning Jiang Bei Fan Xinmin Liu Fengzhong Wang Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice Nutrients soy isoflavones scopolamine learning and memory cholinergic system function oxidative stress ERK/CREB/BDNF pathway |
author_facet |
Cong Lu Yan Wang Donghui Wang Lijing Zhang Jingwei Lv Ning Jiang Bei Fan Xinmin Liu Fengzhong Wang |
author_sort |
Cong Lu |
title |
Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice |
title_short |
Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice |
title_full |
Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice |
title_fullStr |
Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice |
title_full_unstemmed |
Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice |
title_sort |
neuroprotective effects of soy isoflavones on scopolamine-induced amnesia in mice |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-06-01 |
description |
In the recent years, interest in soybean as a neuroprotective nutrient in the management of Alzheimer’s disease (AD) has increased and soy isoflavones (SI), as kinds of soybean phytochemicals, are thought to be biologically active components that confer this beneficial effect against neurodegenerative diseases. However, the neuroprotective effect of SI is not well understood. Therefore, the present study (30 days) was conducted to investigate the neuroprotective effects of soy isoflavones (SI) on scopolamine (SCOP)-induced memory impairments in Institute of Cancer Research (ICR) mice (aged 4 weeks) and to elucidate its underlying mechanisms of action. SI (40 mg/kg) administration improved the cognitive performance of SCOP-treated mice in an object location recognition task and the Morris water maze test. SI (40 mg/kg) administration significantly enhanced cholinergic system function and suppressed oxidative stress levels in the hippocampus of SCOP-treated mice. Furthermore, SI (40 mg/kg) treatment markedly upregulated the phosphorylation levels of extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus. Taken together, these results demonstrated that soy isoflavones exerted a significant neuroprotective effect on cognitive dysfunctions induced by scopolamine, suggesting that soy isoflavones could be a good candidate for possible treatment of neurodegenerative diseases, such as Alzheimer’s disease (AD). |
topic |
soy isoflavones scopolamine learning and memory cholinergic system function oxidative stress ERK/CREB/BDNF pathway |
url |
http://www.mdpi.com/2072-6643/10/7/853 |
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