Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s Experience
Background: We aimed to identify diagnosed cases of ocular cystinosis and describe clinical, epidemiological and therapeutic characteristics. Methods: This is a descriptive and retrospective case series. All patients underwent a full check-up examination every 4–6 months by ophthalmologists, nephrol...
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doaj-b4c3d9df9e9c4440a548fc5050003a262020-11-25T03:56:59ZengMDPI AGDiagnostics2075-44182020-11-011091191110.3390/diagnostics10110911Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s ExperienceMalgorzata Kowalczyk0Mario Damiano Toro1Robert Rejdak2Wojciech Załuska3Caterina Gagliano4Przemyslaw Sikora5Department of General Ophthalmology and Pediatric Ophthalmology Service, Medical University of Lublin, 20079 Lublin, PolandDepartment of General Ophthalmology and Pediatric Ophthalmology Service, Medical University of Lublin, 20079 Lublin, PolandDepartment of General Ophthalmology and Pediatric Ophthalmology Service, Medical University of Lublin, 20079 Lublin, PolandDepartment of Nephrology, Medical University of Lublin, 20954 Lublin, PolandOphthalmology Clinic, San Marco Hospital, University of Catania, 95123 Catania, ItalyDepartment of Pediatric Nephrology, Medical University of Lublin, 20079 Lublin, PolandBackground: We aimed to identify diagnosed cases of ocular cystinosis and describe clinical, epidemiological and therapeutic characteristics. Methods: This is a descriptive and retrospective case series. All patients underwent a full check-up examination every 4–6 months by ophthalmologists, nephrologists and other required specialists. Results: Of the seven cases, six (85.7%) were females and one (14.2%) was male. The infantile nephropathic form of cystinosis was observed in five patients and the juvenile nephropathic form in two patients. No patients with the ocular form of cystinosis were identified. Corneal cystine crystals (CCC) were found in all analyzed patients. Severe ocular and general complications of the disease that had been standing for years, connected to the infantile nephropathic form, delayed diagnosis or inappropriate treatment, were observed only in two patients. All patients received topical therapy. No adverse events related to the therapy were observed. Conclusions: Cystinosis is a rare, progressive disease. Early diagnosis and treatment prevent serious complications from numerous systemic organs. Patients require constant systematic monitoring by various specialists.https://www.mdpi.com/2075-4418/10/11/911cystinosiscorneal depositscysteaminenephropathic cystinosisjuvenile cystinosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Malgorzata Kowalczyk Mario Damiano Toro Robert Rejdak Wojciech Załuska Caterina Gagliano Przemyslaw Sikora |
spellingShingle |
Malgorzata Kowalczyk Mario Damiano Toro Robert Rejdak Wojciech Załuska Caterina Gagliano Przemyslaw Sikora Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s Experience Diagnostics cystinosis corneal deposits cysteamine nephropathic cystinosis juvenile cystinosis |
author_facet |
Malgorzata Kowalczyk Mario Damiano Toro Robert Rejdak Wojciech Załuska Caterina Gagliano Przemyslaw Sikora |
author_sort |
Malgorzata Kowalczyk |
title |
Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s Experience |
title_short |
Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s Experience |
title_full |
Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s Experience |
title_fullStr |
Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s Experience |
title_full_unstemmed |
Ophthalmic Evaluation of Diagnosed Cases of Eye Cystinosis: A Tertiary Care Center’s Experience |
title_sort |
ophthalmic evaluation of diagnosed cases of eye cystinosis: a tertiary care center’s experience |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-11-01 |
description |
Background: We aimed to identify diagnosed cases of ocular cystinosis and describe clinical, epidemiological and therapeutic characteristics. Methods: This is a descriptive and retrospective case series. All patients underwent a full check-up examination every 4–6 months by ophthalmologists, nephrologists and other required specialists. Results: Of the seven cases, six (85.7%) were females and one (14.2%) was male. The infantile nephropathic form of cystinosis was observed in five patients and the juvenile nephropathic form in two patients. No patients with the ocular form of cystinosis were identified. Corneal cystine crystals (CCC) were found in all analyzed patients. Severe ocular and general complications of the disease that had been standing for years, connected to the infantile nephropathic form, delayed diagnosis or inappropriate treatment, were observed only in two patients. All patients received topical therapy. No adverse events related to the therapy were observed. Conclusions: Cystinosis is a rare, progressive disease. Early diagnosis and treatment prevent serious complications from numerous systemic organs. Patients require constant systematic monitoring by various specialists. |
topic |
cystinosis corneal deposits cysteamine nephropathic cystinosis juvenile cystinosis |
url |
https://www.mdpi.com/2075-4418/10/11/911 |
work_keys_str_mv |
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