Autophagy creates a CTL epitope that mimics tumor-associated antigens.
The detailed mechanisms responsible for processing tumor-associated antigens and presenting them to CTLs remain to be fully elucidated. In this study, we demonstrate a unique CTL epitope generated from the ubiquitous protein puromycin-sensitive aminopeptidase, which is presented via HLA-A24 on leuke...
Main Authors: | Ayako Demachi-Okamura, Hiroki Torikai, Yoshiki Akatsuka, Hiroyuki Miyoshi, Tamotsu Yoshimori, Kiyotaka Kuzushima |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3469533?pdf=render |
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