Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in...
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doaj-b4c6c3199d7d45719770f056b5dbac032020-11-25T00:09:43ZengMDPI AGMarine Drugs1660-33972017-01-011511610.3390/md15010016md15010016Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus SpongosoritesAmy E. Wright0K. Brian Killday1Debopam Chakrabarti2Esther A. Guzmán3Dedra Harmody4Peter J. McCarthy5Tara Pitts6Shirley A. Pomponi7John K. Reed8Bracken F. Roberts9Carolina Rodrigues Felix10Kyle H. Rohde11Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USABruker Biospin Corporation, Billerica, MA 01821, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USAA deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.http://www.mdpi.com/1660-3397/15/1/16bis(indole) alkaloidSpongosoritesantibacterialpancreatic cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amy E. Wright K. Brian Killday Debopam Chakrabarti Esther A. Guzmán Dedra Harmody Peter J. McCarthy Tara Pitts Shirley A. Pomponi John K. Reed Bracken F. Roberts Carolina Rodrigues Felix Kyle H. Rohde |
spellingShingle |
Amy E. Wright K. Brian Killday Debopam Chakrabarti Esther A. Guzmán Dedra Harmody Peter J. McCarthy Tara Pitts Shirley A. Pomponi John K. Reed Bracken F. Roberts Carolina Rodrigues Felix Kyle H. Rohde Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites Marine Drugs bis(indole) alkaloid Spongosorites antibacterial pancreatic cancer |
author_facet |
Amy E. Wright K. Brian Killday Debopam Chakrabarti Esther A. Guzmán Dedra Harmody Peter J. McCarthy Tara Pitts Shirley A. Pomponi John K. Reed Bracken F. Roberts Carolina Rodrigues Felix Kyle H. Rohde |
author_sort |
Amy E. Wright |
title |
Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites |
title_short |
Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites |
title_full |
Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites |
title_fullStr |
Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites |
title_full_unstemmed |
Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites |
title_sort |
dragmacidin g, a bioactive bis-indole alkaloid from a deep-water sponge of the genus spongosorites |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2017-01-01 |
description |
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines. |
topic |
bis(indole) alkaloid Spongosorites antibacterial pancreatic cancer |
url |
http://www.mdpi.com/1660-3397/15/1/16 |
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