Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites

A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in...

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Main Authors:	Amy E. Wright, K. Brian Killday, Debopam Chakrabarti, Esther A. Guzmán, Dedra Harmody, Peter J. McCarthy, Tara Pitts, Shirley A. Pomponi, John K. Reed, Bracken F. Roberts, Carolina Rodrigues Felix, Kyle H. Rohde
Format:	Article
Language:	English
Published:	MDPI AG 2017-01-01
Series:	Marine Drugs
Subjects:	bis(indole) alkaloid Spongosorites antibacterial pancreatic cancer
Online Access:	http://www.mdpi.com/1660-3397/15/1/16

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spelling	doaj-b4c6c3199d7d45719770f056b5dbac032020-11-25T00:09:43ZengMDPI AGMarine Drugs1660-33972017-01-011511610.3390/md15010016md15010016Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus SpongosoritesAmy E. Wright0K. Brian Killday1Debopam Chakrabarti2Esther A. Guzmán3Dedra Harmody4Peter J. McCarthy5Tara Pitts6Shirley A. Pomponi7John K. Reed8Bracken F. Roberts9Carolina Rodrigues Felix10Kyle H. Rohde11Harbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USABruker Biospin Corporation, Billerica, MA 01821, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USAHarbor Branch Oceanographic Institute, Florida Atlantic University, Fort Pierce, FL 34946, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827, USAA deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.http://www.mdpi.com/1660-3397/15/1/16bis(indole) alkaloidSpongosoritesantibacterialpancreatic cancer
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Amy E. Wright K. Brian Killday Debopam Chakrabarti Esther A. Guzmán Dedra Harmody Peter J. McCarthy Tara Pitts Shirley A. Pomponi John K. Reed Bracken F. Roberts Carolina Rodrigues Felix Kyle H. Rohde
spellingShingle	Amy E. Wright K. Brian Killday Debopam Chakrabarti Esther A. Guzmán Dedra Harmody Peter J. McCarthy Tara Pitts Shirley A. Pomponi John K. Reed Bracken F. Roberts Carolina Rodrigues Felix Kyle H. Rohde Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites Marine Drugs bis(indole) alkaloid Spongosorites antibacterial pancreatic cancer
author_facet	Amy E. Wright K. Brian Killday Debopam Chakrabarti Esther A. Guzmán Dedra Harmody Peter J. McCarthy Tara Pitts Shirley A. Pomponi John K. Reed Bracken F. Roberts Carolina Rodrigues Felix Kyle H. Rohde
author_sort	Amy E. Wright
title	Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites
title_short	Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites
title_full	Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites
title_fullStr	Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites
title_full_unstemmed	Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites
title_sort	dragmacidin g, a bioactive bis-indole alkaloid from a deep-water sponge of the genus spongosorites
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2017-01-01
description	A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.
topic	bis(indole) alkaloid Spongosorites antibacterial pancreatic cancer
url	http://www.mdpi.com/1660-3397/15/1/16
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Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites

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