Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Keratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that this interaction drives increased keratinocyte pro...

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Main Authors:	Thiviyani Maruthappu, Anissa Chikh, Benjamin Fell, Paul J. Delaney, Matthew A. Brooke, Clemence Levet, Angela Moncada-Pazos, Akemi Ishida-Yamamoto, Diana Blaydon, Ahmad Waseem, Irene M. Leigh, Matthew Freeman, David P. Kelsell
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14174

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spelling	doaj-b4cfedfe8b0b4b1e98605a9262df868a2021-05-11T07:53:25ZengNature Publishing GroupNature Communications2041-17232017-01-018111110.1038/ncomms14174Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16Thiviyani Maruthappu0Anissa Chikh1Benjamin Fell2Paul J. Delaney3Matthew A. Brooke4Clemence Levet5Angela Moncada-Pazos6Akemi Ishida-Yamamoto7Diana Blaydon8Ahmad Waseem9Irene M. Leigh10Matthew Freeman11David P. Kelsell12Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonSir William Dunn School of PathologySir William Dunn School of PathologyDepartment of Dermatology, Asahikawa Medical UniversityCentre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonCentre for Centre Molecular Medicine, Clinical Research Centre, Ninewells Hospital and Medical SchoolSir William Dunn School of PathologyCentre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonKeratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that this interaction drives increased keratinocyte proliferation.https://doi.org/10.1038/ncomms14174
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Thiviyani Maruthappu Anissa Chikh Benjamin Fell Paul J. Delaney Matthew A. Brooke Clemence Levet Angela Moncada-Pazos Akemi Ishida-Yamamoto Diana Blaydon Ahmad Waseem Irene M. Leigh Matthew Freeman David P. Kelsell
spellingShingle	Thiviyani Maruthappu Anissa Chikh Benjamin Fell Paul J. Delaney Matthew A. Brooke Clemence Levet Angela Moncada-Pazos Akemi Ishida-Yamamoto Diana Blaydon Ahmad Waseem Irene M. Leigh Matthew Freeman David P. Kelsell Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16 Nature Communications
author_facet	Thiviyani Maruthappu Anissa Chikh Benjamin Fell Paul J. Delaney Matthew A. Brooke Clemence Levet Angela Moncada-Pazos Akemi Ishida-Yamamoto Diana Blaydon Ahmad Waseem Irene M. Leigh Matthew Freeman David P. Kelsell
author_sort	Thiviyani Maruthappu
title	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_short	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_full	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_fullStr	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_full_unstemmed	Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16
title_sort	rhomboid family member 2 regulates cytoskeletal stress-associated keratin 16
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-01-01
description	Keratin 16 is an epithelial protein highly expressed at pressure bearing sites and during wound healing and cancer. Here the authors show that K16 interacts with the inactive protease Rhbdf2, associated with Tylosis with oesophageal cancer, and that this interaction drives increased keratinocyte proliferation.
url	https://doi.org/10.1038/ncomms14174
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Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

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