Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis
Abstract Background The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs). A connection between the abnormal accumulation of α-synuclein in GCIs and disease initiation and progression has b...
Main Authors: | Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K. Wenning, Nadia Stefanova |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-05-01
|
Series: | BMC Neuroscience |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12868-018-0431-2 |
Similar Items
-
Glia and alpha-synuclein in neurodegeneration: A complex interaction
by: Dominik Brück, et al.
Published: (2016-01-01) -
Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation
by: Huang Yue, et al.
Published: (2012-01-01) -
E46K Mutant α-Synuclein Is Degraded by Both Proteasome and Macroautophagy Pathway
by: Jia-qing Yan, et al.
Published: (2018-11-01) -
Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy
by: Kaji, Seiji
Published: (2018) -
Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions
by: Seiji Kaji, et al.
Published: (2020-02-01)