Soybean Oil-Based Lipid Emulsion Increases Intestinal Permeability of Lipopolysaccharide in Caco-2 Cells by Downregulation of P-Glycoprotein via ERK-FOXO 3a Pathway

Soybean Oil-Based Lipid Emulsion Increases Intestinal Permeability of Lipopolysaccharide in Caco-2 Cells by Downregulation of P-Glycoprotein via ERK-FOXO 3a Pathway

Background and Aims: Elevated intestinal permeability of lipopolysaccharide (LPS) is a major complication for patients with parenteral nutrition (PN), but the pathogenesis is poorly understood. Intestinal P-glycoprotein (P-gp) is one of the efflux transporters that contribute to restricting the perm...

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Bibliographic Details
Main Authors: Jun-Kai Yan, Jie Zhu, Bei-Lin Gu, Wei-Hui Yan, Yong-Tao Xiao, Ke-Jun Zhou, Jie Wen, Yang Wang, Wei Cai
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Parenteral nutrition
Soybean oil-based lipid emulsion
P-glycoprotein
Lipopolysaccharide
Caco-2
Online Access:http://www.karger.com/Article/FullText/447860

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