Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures

Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures

<p>Abstract</p> <p>Background</p> <p>Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasures to nerve agent intoxication increase survival if...

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Bibliographic Details
Main Authors: Meyerhoff James L, Robison Christopher L, Lumley Lucille A, Spradling Kimberly D, Dillman James F
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Journal of Neuroinflammation
Subjects:
Nerve Agent
Chemical Warfare
Organophosphate
Sarin
Piriform Cortex
Seizure
Neuroinflammation
Cytokine
Microarray
Transcriptomics
Online Access:http://www.jneuroinflammation.com/content/8/1/83

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