Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy
Abstract A 46‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis...
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doaj-b50253acdc8749cf9d9d9d15ff1eaabe2020-11-25T03:54:17ZengWileyClinical Case Reports2050-09042020-10-018101997199910.1002/ccr3.3042Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsyIstvan Bodi0Ellen Merete Hagen1Gordon Thorpe Ingle2Michael P Lunn3Clinical Neuropathology King's College Hospital NHS Foundation Trust London UKAutonomic Unit National Hospital for Neurology and Neurosurgery London UKNeurology Department Whipps Cross University Hospital London UKCentre for Neuromuscular Disease National Hospital for Neurology and Neurosurgery London UKAbstract A 46‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated.https://doi.org/10.1002/ccr3.3042autonomic dysfunctionLewy body diseasemultiple system atrophyneurodegenerationParkinson's diseaseα‐synuclein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Istvan Bodi Ellen Merete Hagen Gordon Thorpe Ingle Michael P Lunn |
spellingShingle |
Istvan Bodi Ellen Merete Hagen Gordon Thorpe Ingle Michael P Lunn Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy Clinical Case Reports autonomic dysfunction Lewy body disease multiple system atrophy neurodegeneration Parkinson's disease α‐synuclein |
author_facet |
Istvan Bodi Ellen Merete Hagen Gordon Thorpe Ingle Michael P Lunn |
author_sort |
Istvan Bodi |
title |
Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy |
title_short |
Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy |
title_full |
Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy |
title_fullStr |
Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy |
title_full_unstemmed |
Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy |
title_sort |
fatal autonomic failure due to premanifesting parkinson's disease only diagnosed at autopsy |
publisher |
Wiley |
series |
Clinical Case Reports |
issn |
2050-0904 |
publishDate |
2020-10-01 |
description |
Abstract A 46‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated. |
topic |
autonomic dysfunction Lewy body disease multiple system atrophy neurodegeneration Parkinson's disease α‐synuclein |
url |
https://doi.org/10.1002/ccr3.3042 |
work_keys_str_mv |
AT istvanbodi fatalautonomicfailureduetopremanifestingparkinsonsdiseaseonlydiagnosedatautopsy AT ellenmeretehagen fatalautonomicfailureduetopremanifestingparkinsonsdiseaseonlydiagnosedatautopsy AT gordonthorpeingle fatalautonomicfailureduetopremanifestingparkinsonsdiseaseonlydiagnosedatautopsy AT michaelplunn fatalautonomicfailureduetopremanifestingparkinsonsdiseaseonlydiagnosedatautopsy |
_version_ |
1724474556281782272 |