Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy

Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy

Abstract A 46‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis...

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Main Authors: Istvan Bodi, Ellen Merete Hagen, Gordon Thorpe Ingle, Michael P Lunn
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Clinical Case Reports
Subjects:
autonomic dysfunction
Lewy body disease
multiple system atrophy
neurodegeneration
Parkinson's disease
α‐synuclein
Online Access:https://doi.org/10.1002/ccr3.3042
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spelling doaj-b50253acdc8749cf9d9d9d15ff1eaabe2020-11-25T03:54:17ZengWileyClinical Case Reports2050-09042020-10-018101997199910.1002/ccr3.3042Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsyIstvan Bodi0Ellen Merete Hagen1Gordon Thorpe Ingle2Michael P Lunn3Clinical Neuropathology King's College Hospital NHS Foundation Trust London UKAutonomic Unit National Hospital for Neurology and Neurosurgery London UKNeurology Department Whipps Cross University Hospital London UKCentre for Neuromuscular Disease National Hospital for Neurology and Neurosurgery London UKAbstract A 46‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated.https://doi.org/10.1002/ccr3.3042autonomic dysfunctionLewy body diseasemultiple system atrophyneurodegenerationParkinson's diseaseα‐synuclein
collection DOAJ
language English
format Article
sources DOAJ
author Istvan Bodi
Ellen Merete Hagen
Gordon Thorpe Ingle
Michael P Lunn
spellingShingle Istvan Bodi
Ellen Merete Hagen
Gordon Thorpe Ingle
Michael P Lunn
Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy
Clinical Case Reports
autonomic dysfunction
Lewy body disease
multiple system atrophy
neurodegeneration
Parkinson's disease
α‐synuclein
author_facet Istvan Bodi
Ellen Merete Hagen
Gordon Thorpe Ingle
Michael P Lunn
author_sort Istvan Bodi
title Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy
title_short Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy
title_full Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy
title_fullStr Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy
title_full_unstemmed Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy
title_sort fatal autonomic failure due to premanifesting parkinson's disease only diagnosed at autopsy
publisher Wiley
series Clinical Case Reports
issn 2050-0904
publishDate 2020-10-01
description Abstract A 46‐year‐old male had 11‐year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α‐synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated.
topic autonomic dysfunction
Lewy body disease
multiple system atrophy
neurodegeneration
Parkinson's disease
α‐synuclein
url https://doi.org/10.1002/ccr3.3042
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AT ellenmeretehagen fatalautonomicfailureduetopremanifestingparkinsonsdiseaseonlydiagnosedatautopsy
AT gordonthorpeingle fatalautonomicfailureduetopremanifestingparkinsonsdiseaseonlydiagnosedatautopsy
AT michaelplunn fatalautonomicfailureduetopremanifestingparkinsonsdiseaseonlydiagnosedatautopsy
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