The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation
Alternative splicing of pre-mRNA helps to enhance the genetic diversity within mammalian cells by increasing the number of protein isoforms that can be generated from one gene product. This provides a great deal of flexibility to the host cell to alter protein function, but when dysregulation in spl...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-12-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/17/1/3 |
id |
doaj-b5044c631b3343d1beb06f3d75f79195 |
---|---|
record_format |
Article |
spelling |
doaj-b5044c631b3343d1beb06f3d75f791952020-11-25T02:27:32ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-12-01171310.3390/ijms17010003ijms17010003The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular DifferentiationMehmet Yabas0Hannah Elliott1Gerard F. Hoyne2Department of Immunology and Infectious Disease, the John Curtin School of Medical Research, the Australian National University, Acton 2601, AustraliaSchool of Health Sciences, University of Notre Dame Australia, Fremantle 6959, AustraliaSchool of Health Sciences, University of Notre Dame Australia, Fremantle 6959, AustraliaAlternative splicing of pre-mRNA helps to enhance the genetic diversity within mammalian cells by increasing the number of protein isoforms that can be generated from one gene product. This provides a great deal of flexibility to the host cell to alter protein function, but when dysregulation in splicing occurs this can have important impact on health and disease. Alternative splicing is widely used in the mammalian immune system to control the development and function of antigen specific lymphocytes. In this review we will examine the splicing of pre-mRNAs yielding key proteins in the immune system that regulate apoptosis, lymphocyte differentiation, activation and homeostasis, and discuss how defects in splicing can contribute to diseases. We will describe how disruption to trans-acting factors, such as heterogeneous nuclear ribonucleoproteins (hnRNPs), can impact on cell survival and differentiation in the immune system.http://www.mdpi.com/1422-0067/17/1/3apoptosisB cellsT cellshnRNP proteinsimmune tolerancepre-mRNA alternative splicing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehmet Yabas Hannah Elliott Gerard F. Hoyne |
spellingShingle |
Mehmet Yabas Hannah Elliott Gerard F. Hoyne The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation International Journal of Molecular Sciences apoptosis B cells T cells hnRNP proteins immune tolerance pre-mRNA alternative splicing |
author_facet |
Mehmet Yabas Hannah Elliott Gerard F. Hoyne |
author_sort |
Mehmet Yabas |
title |
The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation |
title_short |
The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation |
title_full |
The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation |
title_fullStr |
The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation |
title_full_unstemmed |
The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation |
title_sort |
role of alternative splicing in the control of immune homeostasis and cellular differentiation |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-12-01 |
description |
Alternative splicing of pre-mRNA helps to enhance the genetic diversity within mammalian cells by increasing the number of protein isoforms that can be generated from one gene product. This provides a great deal of flexibility to the host cell to alter protein function, but when dysregulation in splicing occurs this can have important impact on health and disease. Alternative splicing is widely used in the mammalian immune system to control the development and function of antigen specific lymphocytes. In this review we will examine the splicing of pre-mRNAs yielding key proteins in the immune system that regulate apoptosis, lymphocyte differentiation, activation and homeostasis, and discuss how defects in splicing can contribute to diseases. We will describe how disruption to trans-acting factors, such as heterogeneous nuclear ribonucleoproteins (hnRNPs), can impact on cell survival and differentiation in the immune system. |
topic |
apoptosis B cells T cells hnRNP proteins immune tolerance pre-mRNA alternative splicing |
url |
http://www.mdpi.com/1422-0067/17/1/3 |
work_keys_str_mv |
AT mehmetyabas theroleofalternativesplicinginthecontrolofimmunehomeostasisandcellulardifferentiation AT hannahelliott theroleofalternativesplicinginthecontrolofimmunehomeostasisandcellulardifferentiation AT gerardfhoyne theroleofalternativesplicinginthecontrolofimmunehomeostasisandcellulardifferentiation AT mehmetyabas roleofalternativesplicinginthecontrolofimmunehomeostasisandcellulardifferentiation AT hannahelliott roleofalternativesplicinginthecontrolofimmunehomeostasisandcellulardifferentiation AT gerardfhoyne roleofalternativesplicinginthecontrolofimmunehomeostasisandcellulardifferentiation |
_version_ |
1724842419649773568 |