Recurrent urinary tract infections in healthy and nonpregnant women
Recurrent urinary tract infections (RUTI) are prevalent and pose significant clinical challenges. Although the term RUTI has long been vaguely defined, a consensus definition has emerged in recent years. The exact etiology behind RUTI remains under debate, with valid arguments for both ascending rei...
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Wolters Kluwer Medknow Publications
2014-03-01
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1879522614000037 |
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doaj-b50502a4746f421d8343aeacaa72e78d2020-11-24T22:53:21ZengWolters Kluwer Medknow PublicationsUrological Science1879-52262014-03-012511810.1016/j.urols.2013.11.007Recurrent urinary tract infections in healthy and nonpregnant womenMatthew GloverCristiano G. MoreiraVanessa SperandioPhilippe ZimmernRecurrent urinary tract infections (RUTI) are prevalent and pose significant clinical challenges. Although the term RUTI has long been vaguely defined, a consensus definition has emerged in recent years. The exact etiology behind RUTI remains under debate, with valid arguments for both ascending reinfections as well as persistent infection inside the bladder. These persistent infections exist in the form of quiescent intracellular reservoirs in the mouse model and may represent a novel concept to explain UTI recurrence in humans. Manageable risk factors such as behavioral patterns alongside nonmanageable risk factors including genetic susceptibility are growing fields of investigation. Acute UTI have been studied through two model bacterial strains: Escherichia coli UTI89 and CFT073. However, the clinical relevance to RUTI of these two strains has not been firmly established. Current treatment strategies for RUTI are limited and remain dominated by antibiotic usage despite variable efficacy. The majority of studies in humans have focused on younger groups of women with little information available about the postmenopausal population despite a heightened risk of RUTI in this age group.http://www.sciencedirect.com/science/article/pii/S1879522614000037intracellular bacterial communitiespostmenopausal womenquiescent intracellular reservoirrecurrent urinary tract infectionsreinfectionrisk factors for urinary tract infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthew Glover Cristiano G. Moreira Vanessa Sperandio Philippe Zimmern |
spellingShingle |
Matthew Glover Cristiano G. Moreira Vanessa Sperandio Philippe Zimmern Recurrent urinary tract infections in healthy and nonpregnant women Urological Science intracellular bacterial communities postmenopausal women quiescent intracellular reservoir recurrent urinary tract infections reinfection risk factors for urinary tract infections |
author_facet |
Matthew Glover Cristiano G. Moreira Vanessa Sperandio Philippe Zimmern |
author_sort |
Matthew Glover |
title |
Recurrent urinary tract infections in healthy and nonpregnant women |
title_short |
Recurrent urinary tract infections in healthy and nonpregnant women |
title_full |
Recurrent urinary tract infections in healthy and nonpregnant women |
title_fullStr |
Recurrent urinary tract infections in healthy and nonpregnant women |
title_full_unstemmed |
Recurrent urinary tract infections in healthy and nonpregnant women |
title_sort |
recurrent urinary tract infections in healthy and nonpregnant women |
publisher |
Wolters Kluwer Medknow Publications |
series |
Urological Science |
issn |
1879-5226 |
publishDate |
2014-03-01 |
description |
Recurrent urinary tract infections (RUTI) are prevalent and pose significant clinical challenges. Although the term RUTI has long been vaguely defined, a consensus definition has emerged in recent years. The exact etiology behind RUTI remains under debate, with valid arguments for both ascending reinfections as well as persistent infection inside the bladder. These persistent infections exist in the form of quiescent intracellular reservoirs in the mouse model and may represent a novel concept to explain UTI recurrence in humans. Manageable risk factors such as behavioral patterns alongside nonmanageable risk factors including genetic susceptibility are growing fields of investigation. Acute UTI have been studied through two model bacterial strains: Escherichia coli UTI89 and CFT073. However, the clinical relevance to RUTI of these two strains has not been firmly established. Current treatment strategies for RUTI are limited and remain dominated by antibiotic usage despite variable efficacy. The majority of studies in humans have focused on younger groups of women with little information available about the postmenopausal population despite a heightened risk of RUTI in this age group. |
topic |
intracellular bacterial communities postmenopausal women quiescent intracellular reservoir recurrent urinary tract infections reinfection risk factors for urinary tract infections |
url |
http://www.sciencedirect.com/science/article/pii/S1879522614000037 |
work_keys_str_mv |
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