Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy
Background. Oxidative-nitrative stress and poly (ADP-ribose) polymerase activation have been previously observed in healthy and gestational diabetic pregnancies, and they were also linked to the development of metabolic diseases. The aim of the present study was to examine these parameters and their...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2018/1743253 |
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doaj-b506e43194b048f59b56d1b0474c85722020-11-25T01:03:10ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942018-01-01201810.1155/2018/17432531743253Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after PregnancyEszter M. Horváth0Rita Magenheim1Nóra J. Béres2Rita Benkő3Tamás Pék4Ádám G. Tabák5Csaba Szabo6Department of Physiology, Semmelweis University Faculty of Medicine, Budapest, HungaryDepartment of Medicine, Semmelweis University Faculty of Medicine, Budapest, HungaryInstitute of Human Physiology and Clinical Experimental Research, Semmelweis University Faculty of Medicine, Budapest, HungaryDepartment of Physiology, Semmelweis University Faculty of Medicine, Budapest, HungaryInstitute of Human Physiology and Clinical Experimental Research, Semmelweis University Faculty of Medicine, Budapest, HungaryDepartment of Medicine, Semmelweis University Faculty of Medicine, Budapest, HungaryDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USABackground. Oxidative-nitrative stress and poly (ADP-ribose) polymerase activation have been previously observed in healthy and gestational diabetic pregnancies, and they were also linked to the development of metabolic diseases. The aim of the present study was to examine these parameters and their correlation to known metabolic risk factors following healthy and gestational diabetic pregnancies. Methods. Fasting and 2 h postload plasma total peroxide level, protein tyrosine nitration, and poly (ADP-ribose) polymerase activation were measured in circulating leukocytes three years after delivery in women following healthy, “mild” (diet-treated) or “severe” (insulin-treated) gestational diabetic pregnancy during a standard 75 g OGTT. Nulliparous women and men served as control groups. Results. Fasting plasma total peroxide level was significantly elevated in women with previous pregnancy (B = 0.52 ± 0.13; p<0.001), with further increase in women with insulin-treated gestational diabetes (B=0.36±0.17; p<0.05) (R2=0.419). Its level was independently related to previous pregnancy (B=0.47±0.14; p<0.01) and current CRP levels (B=0.06±0.02; p<0.05) (R2=0.306). Conclusions. Elevated oxidative stress but not nitrative stress or poly (ADP-ribose) polymerase activation can be measured three years after pregnancy. The increased oxidative stress may reflect the cost of reproduction and possibly play a role in the increased metabolic risk observed in women with a history of severe gestational diabetes mellitus.http://dx.doi.org/10.1155/2018/1743253 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eszter M. Horváth Rita Magenheim Nóra J. Béres Rita Benkő Tamás Pék Ádám G. Tabák Csaba Szabo |
spellingShingle |
Eszter M. Horváth Rita Magenheim Nóra J. Béres Rita Benkő Tamás Pék Ádám G. Tabák Csaba Szabo Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy Oxidative Medicine and Cellular Longevity |
author_facet |
Eszter M. Horváth Rita Magenheim Nóra J. Béres Rita Benkő Tamás Pék Ádám G. Tabák Csaba Szabo |
author_sort |
Eszter M. Horváth |
title |
Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy |
title_short |
Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy |
title_full |
Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy |
title_fullStr |
Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy |
title_full_unstemmed |
Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy |
title_sort |
oxidative-nitrative stress and poly (adp-ribose) polymerase activation 3 years after pregnancy |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2018-01-01 |
description |
Background. Oxidative-nitrative stress and poly (ADP-ribose) polymerase activation have been previously observed in healthy and gestational diabetic pregnancies, and they were also linked to the development of metabolic diseases. The aim of the present study was to examine these parameters and their correlation to known metabolic risk factors following healthy and gestational diabetic pregnancies. Methods. Fasting and 2 h postload plasma total peroxide level, protein tyrosine nitration, and poly (ADP-ribose) polymerase activation were measured in circulating leukocytes three years after delivery in women following healthy, “mild” (diet-treated) or “severe” (insulin-treated) gestational diabetic pregnancy during a standard 75 g OGTT. Nulliparous women and men served as control groups. Results. Fasting plasma total peroxide level was significantly elevated in women with previous pregnancy (B = 0.52 ± 0.13; p<0.001), with further increase in women with insulin-treated gestational diabetes (B=0.36±0.17; p<0.05) (R2=0.419). Its level was independently related to previous pregnancy (B=0.47±0.14; p<0.01) and current CRP levels (B=0.06±0.02; p<0.05) (R2=0.306). Conclusions. Elevated oxidative stress but not nitrative stress or poly (ADP-ribose) polymerase activation can be measured three years after pregnancy. The increased oxidative stress may reflect the cost of reproduction and possibly play a role in the increased metabolic risk observed in women with a history of severe gestational diabetes mellitus. |
url |
http://dx.doi.org/10.1155/2018/1743253 |
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