Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue Positions

Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue Positions

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Proteins may be related to each other very specifically as homologous subfamilies. Proteins can also be related to diverse proteins at the super family level. It has become highly important to characterize the existing sequence databases by their signatures to facilitate the function annotation of n...

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Main Authors: Malini Manoharan, Kannan Sankar, Bernard Offmann, Sowdhamini Ramanathan
Format: Article
Language:English
Published: SAGE Publishing 2013-01-01
Series:Bioinformatics and Biology Insights
Online Access:https://doi.org/10.4137/BBI.S11096
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spelling doaj-b509ae02f71743c486ddf586c5459d892020-11-25T03:17:52ZengSAGE PublishingBioinformatics and Biology Insights1177-93222013-01-01710.4137/BBI.S11096Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue PositionsMalini Manoharan0Kannan Sankar1Bernard Offmann2Sowdhamini Ramanathan3Manipal University, Madhav Nagar, Manipal, Karnataka, India.Current address: Iowa State University, Ames, IA, USA.Université de Nantes, UFIP CNRS FRE 3478, Nantes, France.National Centre for Biological Sciences, Tata Institute for Fundamental Research, GKVK campus, Bangalore, INDIA.Proteins may be related to each other very specifically as homologous subfamilies. Proteins can also be related to diverse proteins at the super family level. It has become highly important to characterize the existing sequence databases by their signatures to facilitate the function annotation of newly added sequences. The algorithm described here uses a scheme for the classification of odorant binding proteins on the basis of functional residues and Cys-pairing. The cysteine-based scoring scheme not only helps in unambiguously identifying families like odorant binding proteins (OBPs), but also aids in their classification at the subfamily level with reliable accuracy. The algorithm was also applied to yet another cysteine-rich family, where similar accuracy was observed that ensures the application of the protocol to other families.https://doi.org/10.4137/BBI.S11096
collection DOAJ
language English
format Article
sources DOAJ
author Malini Manoharan
Kannan Sankar
Bernard Offmann
Sowdhamini Ramanathan
spellingShingle Malini Manoharan
Kannan Sankar
Bernard Offmann
Sowdhamini Ramanathan
Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue Positions
Bioinformatics and Biology Insights
author_facet Malini Manoharan
Kannan Sankar
Bernard Offmann
Sowdhamini Ramanathan
author_sort Malini Manoharan
title Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue Positions
title_short Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue Positions
title_full Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue Positions
title_fullStr Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue Positions
title_full_unstemmed Association of Putative Members to Family of Mosquito Odorant Binding Proteins: Scoring Scheme Using Fuzzy Functional Templates and Cys Residue Positions
title_sort association of putative members to family of mosquito odorant binding proteins: scoring scheme using fuzzy functional templates and cys residue positions
publisher SAGE Publishing
series Bioinformatics and Biology Insights
issn 1177-9322
publishDate 2013-01-01
description Proteins may be related to each other very specifically as homologous subfamilies. Proteins can also be related to diverse proteins at the super family level. It has become highly important to characterize the existing sequence databases by their signatures to facilitate the function annotation of newly added sequences. The algorithm described here uses a scheme for the classification of odorant binding proteins on the basis of functional residues and Cys-pairing. The cysteine-based scoring scheme not only helps in unambiguously identifying families like odorant binding proteins (OBPs), but also aids in their classification at the subfamily level with reliable accuracy. The algorithm was also applied to yet another cysteine-rich family, where similar accuracy was observed that ensures the application of the protocol to other families.
url https://doi.org/10.4137/BBI.S11096
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AT kannansankar associationofputativememberstofamilyofmosquitoodorantbindingproteinsscoringschemeusingfuzzyfunctionaltemplatesandcysresiduepositions
AT bernardoffmann associationofputativememberstofamilyofmosquitoodorantbindingproteinsscoringschemeusingfuzzyfunctionaltemplatesandcysresiduepositions
AT sowdhaminiramanathan associationofputativememberstofamilyofmosquitoodorantbindingproteinsscoringschemeusingfuzzyfunctionaltemplatesandcysresiduepositions
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