Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats
Numerous studies suggest that the ingestion of polyphenols can potentially confer haemodynamic benefits. The association between different polyphenolic chemical structures and their physiologic effects on systemic haemodynamic variables and microcirculation are less well known. This study investigat...
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doaj-b50c2ced94b0418f98d010495347601a2021-04-29T04:42:49ZengElsevierJournal of Functional Foods1756-46462014-09-0110355363Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in ratsNozomi Aruga0Megumi Toriigahara1Masahiro Shibata2Takeshi Ishii3Tsutomu Nakayama4Naomi Osakabe5Department of Bio-science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Munumaku, Saitama 337-8570, JapanDepartment of Bio-science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Munumaku, Saitama 337-8570, JapanDepartment of Bio-science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Munumaku, Saitama 337-8570, JapanDepartment of Food and Nutritional Sciences, University of Shizuoka, Yada 52-1, Surugaku, Shizuoka 422-8526, JapanSchool of Food Science and Technology, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino-shi, Tokyo 180-8602, JapanDepartment of Bio-science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Munumaku, Saitama 337-8570, Japan; Correspondence author. Tel.: +81-48-720-6031; fax: +81-48-720-6011..Numerous studies suggest that the ingestion of polyphenols can potentially confer haemodynamic benefits. The association between different polyphenolic chemical structures and their physiologic effects on systemic haemodynamic variables and microcirculation are less well known. This study investigated the effects of a single 10 mg/kg body weight dose of different polyphenolic compounds on haemodynamic and microcirculatory parameters. Key results from laser Doppler flowmetry showed that flavan-3-ols, theaflavins, and quercetin significantly increased cremaster artery blood flow. Flavan 3-ols, theaflavins, (−)-epicatchin, daidzein, and cyanidin significantly elevated mean blood pressure, and flavan-3-ols significantly increased the heart rate. In contrast, hesperidin, epigallocatechin gallate, trans-resveratrol, gnetin C or curcumin did not result in any detectable changes. Our results suggest that polyphenols can contribute variably to alterations in the haemodynamic and microcirculatory status in rats depending on their characteristic chemical structures.http://www.sciencedirect.com/science/article/pii/S1756464614002242Cremaster arteryCremaster muscleMicrocirculationPolyphenolsSystemic circulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nozomi Aruga Megumi Toriigahara Masahiro Shibata Takeshi Ishii Tsutomu Nakayama Naomi Osakabe |
spellingShingle |
Nozomi Aruga Megumi Toriigahara Masahiro Shibata Takeshi Ishii Tsutomu Nakayama Naomi Osakabe Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats Journal of Functional Foods Cremaster artery Cremaster muscle Microcirculation Polyphenols Systemic circulation |
author_facet |
Nozomi Aruga Megumi Toriigahara Masahiro Shibata Takeshi Ishii Tsutomu Nakayama Naomi Osakabe |
author_sort |
Nozomi Aruga |
title |
Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats |
title_short |
Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats |
title_full |
Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats |
title_fullStr |
Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats |
title_full_unstemmed |
Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats |
title_sort |
responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2014-09-01 |
description |
Numerous studies suggest that the ingestion of polyphenols can potentially confer haemodynamic benefits. The association between different polyphenolic chemical structures and their physiologic effects on systemic haemodynamic variables and microcirculation are less well known. This study investigated the effects of a single 10 mg/kg body weight dose of different polyphenolic compounds on haemodynamic and microcirculatory parameters. Key results from laser Doppler flowmetry showed that flavan-3-ols, theaflavins, and quercetin significantly increased cremaster artery blood flow. Flavan 3-ols, theaflavins, (−)-epicatchin, daidzein, and cyanidin significantly elevated mean blood pressure, and flavan-3-ols significantly increased the heart rate. In contrast, hesperidin, epigallocatechin gallate, trans-resveratrol, gnetin C or curcumin did not result in any detectable changes. Our results suggest that polyphenols can contribute variably to alterations in the haemodynamic and microcirculatory status in rats depending on their characteristic chemical structures. |
topic |
Cremaster artery Cremaster muscle Microcirculation Polyphenols Systemic circulation |
url |
http://www.sciencedirect.com/science/article/pii/S1756464614002242 |
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