Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint
Objective To develop a thermochromic tissue-mimicking phantom (TTMP) with an embedded 3D-printed bone mimic of the lumbar spine to evaluate MRgFUS ablation of the facet joint and medial branch nerve. Materials and methods Multiple 3D-printed materials were selected and characterized by measurements...
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doaj-b513295f40d645639ad6e905f81afb6b2021-02-08T14:09:05ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572021-01-0138113013510.1080/02656736.2021.18806501880650Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet jointWendy Zhang0Hari Trivedi1Matthew Adams2Aaron D. Losey3Chris J. Diederich4Eugene Ozhinsky5Viola Rieke6Matthew D. Bucknor7New York Medical CollegeDepartment of Radiology and Imaging Science, Emory University HospitalDepartment of Radiation Oncology, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Radiation Oncology, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaDepartment of Radiology and Biomedical Imaging, University of CaliforniaObjective To develop a thermochromic tissue-mimicking phantom (TTMP) with an embedded 3D-printed bone mimic of the lumbar spine to evaluate MRgFUS ablation of the facet joint and medial branch nerve. Materials and methods Multiple 3D-printed materials were selected and characterized by measurements of speed of sound and linear acoustic attenuation coefficient using a through-transmission technique. A 3D model of the lumbar spine was segmented from a de-identified CT scan, and 3D printed. The 3D-printed spine was embedded within a TTMP with thermochromic ink color change setpoint at 60 °C. Multiple high energy sonications were targeted to the facet joints and medial branch nerve anatomical location using an ExAblate MRgFUS system connected to a 3T MR scanner. The phantom was dissected to assess sonication targets and the surrounding structures for color change as compared to the expected region of ablation on MR-thermometry. Results The measured sound attenuation coefficient and speed of sound of gypsum was 240 Np/m-MHz and 2471 m/s, which is the closest to published values for cortical bone. Following sonication, dissection of the TTMP revealed good concordance between the regions of color change within the phantom and expected areas of ablation on MR-thermometry. No heat deposition was observed in critical areas, including the spinal canal and nerve roots from either color change or MRI. Conclusion Ablated regions in the TTMP correlated well with expected ablations based on MR-thermometry. These findings demonstrate the utility of an anatomic spine phantom in evaluating MRgFUS sonication for facet joint and medial branch nerve ablations.http://dx.doi.org/10.1080/02656736.2021.1880650chronic low back pain (lbp)mri-guided focused ultrasound surgery (mrgfus)thermochromic tissue-mimicking phantom (ttmp)3d-printed modelpre-clinical evaluation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wendy Zhang Hari Trivedi Matthew Adams Aaron D. Losey Chris J. Diederich Eugene Ozhinsky Viola Rieke Matthew D. Bucknor |
spellingShingle |
Wendy Zhang Hari Trivedi Matthew Adams Aaron D. Losey Chris J. Diederich Eugene Ozhinsky Viola Rieke Matthew D. Bucknor Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint International Journal of Hyperthermia chronic low back pain (lbp) mri-guided focused ultrasound surgery (mrgfus) thermochromic tissue-mimicking phantom (ttmp) 3d-printed model pre-clinical evaluation |
author_facet |
Wendy Zhang Hari Trivedi Matthew Adams Aaron D. Losey Chris J. Diederich Eugene Ozhinsky Viola Rieke Matthew D. Bucknor |
author_sort |
Wendy Zhang |
title |
Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint |
title_short |
Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint |
title_full |
Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint |
title_fullStr |
Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint |
title_full_unstemmed |
Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint |
title_sort |
anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of mr-guided focused ultrasound (mrgfus) ablation of the facet joint |
publisher |
Taylor & Francis Group |
series |
International Journal of Hyperthermia |
issn |
0265-6736 1464-5157 |
publishDate |
2021-01-01 |
description |
Objective To develop a thermochromic tissue-mimicking phantom (TTMP) with an embedded 3D-printed bone mimic of the lumbar spine to evaluate MRgFUS ablation of the facet joint and medial branch nerve. Materials and methods Multiple 3D-printed materials were selected and characterized by measurements of speed of sound and linear acoustic attenuation coefficient using a through-transmission technique. A 3D model of the lumbar spine was segmented from a de-identified CT scan, and 3D printed. The 3D-printed spine was embedded within a TTMP with thermochromic ink color change setpoint at 60 °C. Multiple high energy sonications were targeted to the facet joints and medial branch nerve anatomical location using an ExAblate MRgFUS system connected to a 3T MR scanner. The phantom was dissected to assess sonication targets and the surrounding structures for color change as compared to the expected region of ablation on MR-thermometry. Results The measured sound attenuation coefficient and speed of sound of gypsum was 240 Np/m-MHz and 2471 m/s, which is the closest to published values for cortical bone. Following sonication, dissection of the TTMP revealed good concordance between the regions of color change within the phantom and expected areas of ablation on MR-thermometry. No heat deposition was observed in critical areas, including the spinal canal and nerve roots from either color change or MRI. Conclusion Ablated regions in the TTMP correlated well with expected ablations based on MR-thermometry. These findings demonstrate the utility of an anatomic spine phantom in evaluating MRgFUS sonication for facet joint and medial branch nerve ablations. |
topic |
chronic low back pain (lbp) mri-guided focused ultrasound surgery (mrgfus) thermochromic tissue-mimicking phantom (ttmp) 3d-printed model pre-clinical evaluation |
url |
http://dx.doi.org/10.1080/02656736.2021.1880650 |
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