Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats
Intracerebral hemorrhage (ICH) may be caused by trauma, aneurysm and arteriovenous malformation, as can any bleeding within the intracranial vault, including brain parenchyma and adjacent meningeal spaces (aneurism and atreovenous malformation). ICH is the cerebral stroke with the least treatable fo...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-06-01
|
Series: | IBRO Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2451830120300078 |
id |
doaj-b51fb16919d349559a385b0268ac6607 |
---|---|
record_format |
Article |
spelling |
doaj-b51fb16919d349559a385b0268ac66072020-11-25T02:24:28ZengElsevierIBRO Reports2451-83012020-06-018101114Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in ratsKajal Rajdev0Ehraz Mehmood Siddiqui1Kuldeep Singh Jadaun2Sidharth Mehan3Neuropharmacology Division, ISF College of Pharmacy, Moga, 142001 Punjab, IndiaNeuropharmacology Division, ISF College of Pharmacy, Moga, 142001 Punjab, IndiaNeuropharmacology Division, ISF College of Pharmacy, Moga, 142001 Punjab, IndiaCorresponding author.; Neuropharmacology Division, ISF College of Pharmacy, Moga, 142001 Punjab, IndiaIntracerebral hemorrhage (ICH) may be caused by trauma, aneurysm and arteriovenous malformation, as can any bleeding within the intracranial vault, including brain parenchyma and adjacent meningeal spaces (aneurism and atreovenous malformation). ICH is the cerebral stroke with the least treatable form. Over time, intraventricular hemorrhage (IVH) is associated with ICH, which contributes to hydrocephalus, and the major cause of most hemorrhagic death (Due to the cerebral hemorrhage and post hemorrhagic surgeries). Most patients suffer from memory impairment, grip strength, posture, and cognitive dysfunctions attributable to cerebral hemorrhage or post-brain hemorrhagic surgery. Nevertheless, a combined model of ICH based IVH is not present pre-clinically. Autologous blood (ALB) injection (20 μl/5 min) in the rat brain triggers hemorrhage, such as factors that further interfere with the normal functioning of neuroinflammatory cytokines, oxidative stress, and neurotransmitter dysfunction, such as CoQ10 insufficiency and dysregulation of mitochondrial ETC-complexes. For the prevention of post-brain hemorrhagic behavioral and neurochemical dysfunctions, there is no specific drug treatment available, only available therapy used to provide symptomatic relief. The current study reveals that long-term administration of Solanesol (SNL) 40 and 60 mg/kg alone and in combination with available drug therapy Donepezil (DNP) 3 mg/kg, Memantine (MEM) 20 mg/kg, Celecoxib (CLB) 20 mg/kg, Pregabalin (PGB) 30 mg/kg, may provide the neuroprotective effect by improving behavioral and neurochemical deficits, and gross pathological changes in ALB induced combined experimental model of ICH-IVH in post brain hemorrhagic conditions in rats. Thus, SNL can be a potential therapeutic approach to improve neuronal mitochondrial dysfunction associated with post brain hemorrhagic behavioral and neurochemical alterations.http://www.sciencedirect.com/science/article/pii/S2451830120300078Intracerebral-Intraventricular hemorrhageMitochondrial dysfunctionOxidative stressSolanesolCelecoxibPregabalin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kajal Rajdev Ehraz Mehmood Siddiqui Kuldeep Singh Jadaun Sidharth Mehan |
spellingShingle |
Kajal Rajdev Ehraz Mehmood Siddiqui Kuldeep Singh Jadaun Sidharth Mehan Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats IBRO Reports Intracerebral-Intraventricular hemorrhage Mitochondrial dysfunction Oxidative stress Solanesol Celecoxib Pregabalin |
author_facet |
Kajal Rajdev Ehraz Mehmood Siddiqui Kuldeep Singh Jadaun Sidharth Mehan |
author_sort |
Kajal Rajdev |
title |
Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats |
title_short |
Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats |
title_full |
Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats |
title_fullStr |
Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats |
title_full_unstemmed |
Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats |
title_sort |
neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats |
publisher |
Elsevier |
series |
IBRO Reports |
issn |
2451-8301 |
publishDate |
2020-06-01 |
description |
Intracerebral hemorrhage (ICH) may be caused by trauma, aneurysm and arteriovenous malformation, as can any bleeding within the intracranial vault, including brain parenchyma and adjacent meningeal spaces (aneurism and atreovenous malformation). ICH is the cerebral stroke with the least treatable form. Over time, intraventricular hemorrhage (IVH) is associated with ICH, which contributes to hydrocephalus, and the major cause of most hemorrhagic death (Due to the cerebral hemorrhage and post hemorrhagic surgeries). Most patients suffer from memory impairment, grip strength, posture, and cognitive dysfunctions attributable to cerebral hemorrhage or post-brain hemorrhagic surgery. Nevertheless, a combined model of ICH based IVH is not present pre-clinically. Autologous blood (ALB) injection (20 μl/5 min) in the rat brain triggers hemorrhage, such as factors that further interfere with the normal functioning of neuroinflammatory cytokines, oxidative stress, and neurotransmitter dysfunction, such as CoQ10 insufficiency and dysregulation of mitochondrial ETC-complexes. For the prevention of post-brain hemorrhagic behavioral and neurochemical dysfunctions, there is no specific drug treatment available, only available therapy used to provide symptomatic relief. The current study reveals that long-term administration of Solanesol (SNL) 40 and 60 mg/kg alone and in combination with available drug therapy Donepezil (DNP) 3 mg/kg, Memantine (MEM) 20 mg/kg, Celecoxib (CLB) 20 mg/kg, Pregabalin (PGB) 30 mg/kg, may provide the neuroprotective effect by improving behavioral and neurochemical deficits, and gross pathological changes in ALB induced combined experimental model of ICH-IVH in post brain hemorrhagic conditions in rats. Thus, SNL can be a potential therapeutic approach to improve neuronal mitochondrial dysfunction associated with post brain hemorrhagic behavioral and neurochemical alterations. |
topic |
Intracerebral-Intraventricular hemorrhage Mitochondrial dysfunction Oxidative stress Solanesol Celecoxib Pregabalin |
url |
http://www.sciencedirect.com/science/article/pii/S2451830120300078 |
work_keys_str_mv |
AT kajalrajdev neuroprotectivepotentialofsolanesolinacombinedmodelofintracerebralandintraventricularhemorrhageinrats AT ehrazmehmoodsiddiqui neuroprotectivepotentialofsolanesolinacombinedmodelofintracerebralandintraventricularhemorrhageinrats AT kuldeepsinghjadaun neuroprotectivepotentialofsolanesolinacombinedmodelofintracerebralandintraventricularhemorrhageinrats AT sidharthmehan neuroprotectivepotentialofsolanesolinacombinedmodelofintracerebralandintraventricularhemorrhageinrats |
_version_ |
1724855664281387008 |