Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques
Studying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for n...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-01-01
|
Series: | Frontiers in Cellular and Infection Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2018.00440/full |
id |
doaj-b5239c72694848828fa6f0cebf4bc683 |
---|---|
record_format |
Article |
spelling |
doaj-b5239c72694848828fa6f0cebf4bc6832020-11-25T01:00:52ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882019-01-01810.3389/fcimb.2018.00440428491Mapping Arbovirus-Vector Interactions Using Systems Biology TechniquesMarine J. Petit0Marine J. Petit1Priya S. Shah2Priya S. Shah3Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, United StatesDepartment of Chemical Engineering, University of California, Davis, Davis, CA, United StatesDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, United StatesDepartment of Chemical Engineering, University of California, Davis, Davis, CA, United StatesStudying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for non-model viruses and non-model organisms. Advances in systems biology “-omics”-based techniques such as next-generation sequencing (NGS) and mass spectrometry can rapidly provide an unbiased view of arbovirus-vector interaction landscapes. In this mini-review, we discuss how arbovirus-vector interaction studies have been advanced by systems biology. We review studies of arbovirus-vector interactions that occur at multiple time and length scales, including intracellular interactions, interactions at the level of the organism, viral and vector populations, and how new techniques can integrate systems-level data across these different scales.https://www.frontiersin.org/article/10.3389/fcimb.2018.00440/fullarbovirusvirusarthropodvectorinteractionssystems biology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marine J. Petit Marine J. Petit Priya S. Shah Priya S. Shah |
spellingShingle |
Marine J. Petit Marine J. Petit Priya S. Shah Priya S. Shah Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques Frontiers in Cellular and Infection Microbiology arbovirus virus arthropod vector interactions systems biology |
author_facet |
Marine J. Petit Marine J. Petit Priya S. Shah Priya S. Shah |
author_sort |
Marine J. Petit |
title |
Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_short |
Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_full |
Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_fullStr |
Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_full_unstemmed |
Mapping Arbovirus-Vector Interactions Using Systems Biology Techniques |
title_sort |
mapping arbovirus-vector interactions using systems biology techniques |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2019-01-01 |
description |
Studying how arthropod-borne viruses interact with their arthropod vectors is critical to understanding how these viruses replicate and are transmitted. Until recently, these types of studies were limited in scale because of the lack of classical tools available to study virus-host interaction for non-model viruses and non-model organisms. Advances in systems biology “-omics”-based techniques such as next-generation sequencing (NGS) and mass spectrometry can rapidly provide an unbiased view of arbovirus-vector interaction landscapes. In this mini-review, we discuss how arbovirus-vector interaction studies have been advanced by systems biology. We review studies of arbovirus-vector interactions that occur at multiple time and length scales, including intracellular interactions, interactions at the level of the organism, viral and vector populations, and how new techniques can integrate systems-level data across these different scales. |
topic |
arbovirus virus arthropod vector interactions systems biology |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2018.00440/full |
work_keys_str_mv |
AT marinejpetit mappingarbovirusvectorinteractionsusingsystemsbiologytechniques AT marinejpetit mappingarbovirusvectorinteractionsusingsystemsbiologytechniques AT priyasshah mappingarbovirusvectorinteractionsusingsystemsbiologytechniques AT priyasshah mappingarbovirusvectorinteractionsusingsystemsbiologytechniques |
_version_ |
1725212245680455680 |