<i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-Analysis
<i>Background and Objectives:</i> To perform a systematic review and meta-analysis with the aim of determining the relationship between <i>H. pylori</i> infection and psoriasis. <i>Methods</i>: Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and We...
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doaj-b530dcf7b6e14cac9597225e2fdddc062020-11-24T21:55:32ZengMDPI AGMedicina1010-660X2019-09-01551064510.3390/medicina55100645medicina55100645<i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-AnalysisMingyang Yu0Rongguang Zhang1Peng Ni2Shuaiyin Chen3Guangcai Duan4Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China<i>Background and Objectives:</i> To perform a systematic review and meta-analysis with the aim of determining the relationship between <i>H. pylori</i> infection and psoriasis. <i>Methods</i>: Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Web of Science were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. <i>Results</i>: The initial database search resulted in 204 articles. Through exclusion and screening, 11 studies involving a total of 1741 participants were finally included in this meta-analysis. The odds ratio (OR) of <i>H. pylori</i> infection rate in the psoriasis group was significantly higher than that in the control group (OR = 1.19, 95% CI 1.15−2.52, <i>P</i> = 0.008). Subgroup analysis showed that no significant difference was detected between the Asia group and the Europe group. As for the methods of <i>H. pylori</i> detection, a statistically significant increase of <i>H. pylori</i> infection in the IgG ELISA test group was detected, compared with the urea breath test group. In addition, analysis based on the severity of psoriasis showed a statistically significant increase of <i>H. pylori</i> infection in moderate and severe psoriasis patients (OR = 2.27; 95% CI: 1.42−3.63, <i>I</i><sup>2</sup> = 27%), but not in the mild psoriasis patients (OR = 1.10; 95% CI: 0.79−1.54, <i>I</i><sup>2</sup> = 0%). <i>Conclusion</i>: <i>H. pylori</i> infection is associated with psoriasis, and psoriasis patients with <i>H. pylori</i> infection have higher Psoriasis Area and Severity Index (PASI) scores. The findings are of considerable significance for the clinical practices.https://www.mdpi.com/1010-660X/55/10/645<i>helicobacter pylori</i>infectionpsoriasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mingyang Yu Rongguang Zhang Peng Ni Shuaiyin Chen Guangcai Duan |
spellingShingle |
Mingyang Yu Rongguang Zhang Peng Ni Shuaiyin Chen Guangcai Duan <i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-Analysis Medicina <i>helicobacter pylori</i> infection psoriasis |
author_facet |
Mingyang Yu Rongguang Zhang Peng Ni Shuaiyin Chen Guangcai Duan |
author_sort |
Mingyang Yu |
title |
<i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-Analysis |
title_short |
<i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-Analysis |
title_full |
<i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-Analysis |
title_fullStr |
<i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
<i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-Analysis |
title_sort |
<i>helicobacter pylori</i> infection and psoriasis: a systematic review and meta-analysis |
publisher |
MDPI AG |
series |
Medicina |
issn |
1010-660X |
publishDate |
2019-09-01 |
description |
<i>Background and Objectives:</i> To perform a systematic review and meta-analysis with the aim of determining the relationship between <i>H. pylori</i> infection and psoriasis. <i>Methods</i>: Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Web of Science were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. <i>Results</i>: The initial database search resulted in 204 articles. Through exclusion and screening, 11 studies involving a total of 1741 participants were finally included in this meta-analysis. The odds ratio (OR) of <i>H. pylori</i> infection rate in the psoriasis group was significantly higher than that in the control group (OR = 1.19, 95% CI 1.15−2.52, <i>P</i> = 0.008). Subgroup analysis showed that no significant difference was detected between the Asia group and the Europe group. As for the methods of <i>H. pylori</i> detection, a statistically significant increase of <i>H. pylori</i> infection in the IgG ELISA test group was detected, compared with the urea breath test group. In addition, analysis based on the severity of psoriasis showed a statistically significant increase of <i>H. pylori</i> infection in moderate and severe psoriasis patients (OR = 2.27; 95% CI: 1.42−3.63, <i>I</i><sup>2</sup> = 27%), but not in the mild psoriasis patients (OR = 1.10; 95% CI: 0.79−1.54, <i>I</i><sup>2</sup> = 0%). <i>Conclusion</i>: <i>H. pylori</i> infection is associated with psoriasis, and psoriasis patients with <i>H. pylori</i> infection have higher Psoriasis Area and Severity Index (PASI) scores. The findings are of considerable significance for the clinical practices. |
topic |
<i>helicobacter pylori</i> infection psoriasis |
url |
https://www.mdpi.com/1010-660X/55/10/645 |
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