<i>Helicobacter pylori</i> Infection and Psoriasis: A Systematic Review and Meta-Analysis

• Main Authors: Mingyang Yu, Rongguang Zhang, Peng Ni, Shuaiyin Chen, Guangcai Duan
• Format: Article
• Language: English
• Published: MDPI AG 2019-09-01
• Series: Medicina
• Subjects: <i>helicobacter pylori</i>; infection; psoriasis
• Online Access: https://www.mdpi.com/1010-660X/55/10/645

<i>Background and Objectives:</i> To perform a systematic review and meta-analysis with the aim of determining the relationship between <i>H. pylori</i> infection and psoriasis. <i>Methods</i>: Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Web of Science were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. <i>Results</i>: The initial database search resulted in 204 articles. Through exclusion and screening, 11 studies involving a total of 1741 participants were finally included in this meta-analysis. The odds ratio (OR) of <i>H. pylori</i> infection rate in the psoriasis group was significantly higher than that in the control group (OR = 1.19, 95% CI 1.15&#8722;2.52, <i>P</i> = 0.008). Subgroup analysis showed that no significant difference was detected between the Asia group and the Europe group. As for the methods of <i>H. pylori</i> detection, a statistically significant increase of <i>H. pylori</i> infection in the IgG ELISA test group was detected, compared with the urea breath test group. In addition, analysis based on the severity of psoriasis showed a statistically significant increase of <i>H. pylori</i> infection in moderate and severe psoriasis patients (OR = 2.27; 95% CI: 1.42&#8722;3.63, <i>I</i>² = 27%), but not in the mild psoriasis patients (OR = 1.10; 95% CI: 0.79&#8722;1.54, <i>I</i>² = 0%). <i>Conclusion</i>: <i>H. pylori</i> infection is associated with psoriasis, and psoriasis patients with <i>H. pylori</i> infection have higher Psoriasis Area and Severity Index (PASI) scores. The findings are of considerable significance for the clinical practices.