Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C
Several studies have demonstrated that HIV/hepatitis C virus (HCV)-coinfected patients experience more rapid fibrosis progression. In this study, to estimate the annual rate of direct liver fibrosis progression, we used analyses of paired biopsy samples from HIV/HCV-coinfected patients without prior...
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doaj-b5375e9a6f434b8bb45e010e96af36cc2020-11-25T03:03:23ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95742325-95822015-09-011410.1177/2325957415587571Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis CAndréa G. B. Leite0Maria Irma S. Duarte1Maria Cássia Mendes-Correa2Departamento de Doenças infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrasilDepartamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, BrasilDepartamento de Doenças infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrasilSeveral studies have demonstrated that HIV/hepatitis C virus (HCV)-coinfected patients experience more rapid fibrosis progression. In this study, to estimate the annual rate of direct liver fibrosis progression, we used analyses of paired biopsy samples from HIV/HCV-coinfected patients without prior treatment of hepatitis and assessed the possible association of fibrosis progression with certain clinical variables. We evaluated 30 HIV/HCV-coinfected patients, with no history of prior treatment of hepatitis C, who underwent paired liver biopsies. All patients were under antiretroviral therapy at first and second biopsies. The average annual progression rate was 0.13 fibrosis unit/year, with 36.7% of patients defined as progressors. Liver fibrosis progression was associated with alanine aminotransferase (ALT; P < .001) and aspartate aminotransferase (AST; P < .0340) levels over 3 times the upper limit of normal present at first biopsy. Elevated ALT and AST levels appear to be associated with more accelerated liver fibrosis progression among HIV/HCV-coinfected patients.https://doi.org/10.1177/2325957415587571 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andréa G. B. Leite Maria Irma S. Duarte Maria Cássia Mendes-Correa |
spellingShingle |
Andréa G. B. Leite Maria Irma S. Duarte Maria Cássia Mendes-Correa Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C Journal of the International Association of Providers of AIDS Care |
author_facet |
Andréa G. B. Leite Maria Irma S. Duarte Maria Cássia Mendes-Correa |
author_sort |
Andréa G. B. Leite |
title |
Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C |
title_short |
Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C |
title_full |
Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C |
title_fullStr |
Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C |
title_full_unstemmed |
Fibrosis Progression in Paired Liver Biopsies from HIV/HCV-Coinfected Patients without Prior Treatment of Hepatitis C |
title_sort |
fibrosis progression in paired liver biopsies from hiv/hcv-coinfected patients without prior treatment of hepatitis c |
publisher |
SAGE Publishing |
series |
Journal of the International Association of Providers of AIDS Care |
issn |
2325-9574 2325-9582 |
publishDate |
2015-09-01 |
description |
Several studies have demonstrated that HIV/hepatitis C virus (HCV)-coinfected patients experience more rapid fibrosis progression. In this study, to estimate the annual rate of direct liver fibrosis progression, we used analyses of paired biopsy samples from HIV/HCV-coinfected patients without prior treatment of hepatitis and assessed the possible association of fibrosis progression with certain clinical variables. We evaluated 30 HIV/HCV-coinfected patients, with no history of prior treatment of hepatitis C, who underwent paired liver biopsies. All patients were under antiretroviral therapy at first and second biopsies. The average annual progression rate was 0.13 fibrosis unit/year, with 36.7% of patients defined as progressors. Liver fibrosis progression was associated with alanine aminotransferase (ALT; P < .001) and aspartate aminotransferase (AST; P < .0340) levels over 3 times the upper limit of normal present at first biopsy. Elevated ALT and AST levels appear to be associated with more accelerated liver fibrosis progression among HIV/HCV-coinfected patients. |
url |
https://doi.org/10.1177/2325957415587571 |
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