The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity
Background. Red cell distribution width (RDW) and platelet-lymphocyte ratio (PLR) have been studied in a variety of etiological diseases. We aim to investigate the relationship between RDW and PLR and the severity of hepatitis C virus- (HCV-) related liver disease. Methods. We included fifty-two chr...
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doaj-b54473deef6e475a97f924ba3bbf45592020-11-24T23:41:34ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/29784792978479The Relationship between Inflammatory Marker Levels and Hepatitis C Virus SeverityQitian He0Quan He1Xue Qin2Shan Li3Taijie Li4Li Xie5Yan Deng6Yu He7Yongbin Chen8Zhifu Wei9Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Traditional Chinese Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Traditional Chinese Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Infection Control, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaBackground. Red cell distribution width (RDW) and platelet-lymphocyte ratio (PLR) have been studied in a variety of etiological diseases. We aim to investigate the relationship between RDW and PLR and the severity of hepatitis C virus- (HCV-) related liver disease. Methods. We included fifty-two chronic HCV and 42 HCV-related cirrhosis patients and 84 healthy controls. Hematological and virological parameters and liver function biomarkers of HCV-related patients at admission were recorded. Results. RDW, RDW-to-platelet (RPR), and 1/PLR values in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients and healthy controls (all P<0.001). The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), and fibrosis index based on the four factors (FIB-4) scores in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients (all P<0.001). The areas under the curve of the RDW, RPR, and 1/PLR for predicting cirrhosis were 0.791, 0.960, and 0.713, respectively. Bivariate logistic regression analysis showed that RDW could independently predict the presence of cirrhosis in chronic HCV patients. Conclusions. RDW, RPR, and PLR may be potential markers for estimating HCV severity.http://dx.doi.org/10.1155/2016/2978479 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qitian He Quan He Xue Qin Shan Li Taijie Li Li Xie Yan Deng Yu He Yongbin Chen Zhifu Wei |
spellingShingle |
Qitian He Quan He Xue Qin Shan Li Taijie Li Li Xie Yan Deng Yu He Yongbin Chen Zhifu Wei The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity Gastroenterology Research and Practice |
author_facet |
Qitian He Quan He Xue Qin Shan Li Taijie Li Li Xie Yan Deng Yu He Yongbin Chen Zhifu Wei |
author_sort |
Qitian He |
title |
The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity |
title_short |
The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity |
title_full |
The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity |
title_fullStr |
The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity |
title_full_unstemmed |
The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity |
title_sort |
relationship between inflammatory marker levels and hepatitis c virus severity |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2016-01-01 |
description |
Background. Red cell distribution width (RDW) and platelet-lymphocyte ratio (PLR) have been studied in a variety of etiological diseases. We aim to investigate the relationship between RDW and PLR and the severity of hepatitis C virus- (HCV-) related liver disease. Methods. We included fifty-two chronic HCV and 42 HCV-related cirrhosis patients and 84 healthy controls. Hematological and virological parameters and liver function biomarkers of HCV-related patients at admission were recorded. Results. RDW, RDW-to-platelet (RPR), and 1/PLR values in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients and healthy controls (all P<0.001). The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), and fibrosis index based on the four factors (FIB-4) scores in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients (all P<0.001). The areas under the curve of the RDW, RPR, and 1/PLR for predicting cirrhosis were 0.791, 0.960, and 0.713, respectively. Bivariate logistic regression analysis showed that RDW could independently predict the presence of cirrhosis in chronic HCV patients. Conclusions. RDW, RPR, and PLR may be potential markers for estimating HCV severity. |
url |
http://dx.doi.org/10.1155/2016/2978479 |
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