A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer

A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer

A small of population of slow cycling and chemo-resistant cells referred to as cancer stem cells (CSC) have been implicated in cancer recurrence. There is emerging interest in developing targeted therapeutics to eradicate CSCs. Aldehyde-dehydrogenase (ALDH) activity was shown to be a functional mark...

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Bibliographic Details
Main Authors: Nkechiyere G. Nwani, Salvatore Condello, Yinu Wang, Wendy M. Swetzig, Emma Barber, Thomas Hurley, Daniela Matei
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
ovarian cancer
ALDH1A1
CM37
cancer stem cells
Online Access:https://www.mdpi.com/2072-6694/11/4/502

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