No effect of 10 weeks erythropoietin treatment on lipid oxidation in healthy men

• Main Authors: Jeyanthini Risikesan, Birgitte Nellemann, Britt Christensen, Jens Otto Lunde Jørgensen, Søren Nielsen
• Format: Article
• Language: English
• Published: Bioscientifica 2020-12-01
• Series: Endocrine Connections
• Subjects: erythropoietin; lipids; vldl-tg; energy expenditure
• Online Access: https://ec.bioscientifica.com/view/journals/ec/9/12/EC-20-0305.xml

Studies indicate that erythropoietin (EPO) has effect on lipid a nd energy metabolism; however, the impact of EPO on lipid oxidation in vivo has not been well documented. Here, we evaluate whether long-term erythropoiesis-stimulating agent (ESA) treatment affects the oxidation of plasma very low-density lipoprotein triglycerides (VLDL-TG) fatty acids (FA), plasma free fatty acids (FFA) and non-plasma (residual) FA in healthy, young, sedentary men. Infusion of [1-14C]VLDL-TG and [9,10-3H]palmitate was used in combination with indirect calorimetry to assess resting lipid fuel utilization and kinetics, and resting energy expenditure (REE) before and after 10 weeks of ESA exposure compared with placebo. REE increased significantly during ESA compared with placebo ( P = 0.023, RM-ANOVA). Oxidation rates of VLDL-TG FA, FFA, and residual FA remained unchanged during ESA compared with placebo. The relative contribution of the lipid stores was greatest for FFA (47.1%) and the total lipid oxidation rate and was not significa ntly different between ESA and placebo-treated subjects. We conclude that long-term ESA treatment of healthy young men increases REE but does not alter the oxidation rates of plasma and non-plasma FA sources.