Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary Hospital
In addition to the increase in fungal infections that has been observed in the last few decades, it has been reported that severe clinical COVID-19 can increase the risk of invasive fungal infections. The main objective of this study was to evaluate if there had been an increase in candidaemia and i...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
|
Series: | Journal of Fungi |
Subjects: | |
Online Access: | https://www.mdpi.com/2309-608X/7/6/440 |
id |
doaj-b54c6d6eecc34def8aa590eb17e2d625 |
---|---|
record_format |
Article |
spelling |
doaj-b54c6d6eecc34def8aa590eb17e2d6252021-06-01T01:46:06ZengMDPI AGJournal of Fungi2309-608X2021-05-01744044010.3390/jof7060440Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary HospitalJuan Vicente Mulet Bayona0Nuria Tormo Palop1Carme Salvador García2Begoña Fuster Escrivá3Mercedes Chanzá Aviñó4Pilar Ortega García5Concepción Gimeno Cardona6Department of Microbiology and Parasitology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, SpainDepartment of Microbiology and Parasitology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, SpainDepartment of Microbiology and Parasitology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, SpainDepartment of Microbiology and Parasitology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, SpainDepartment of Microbiology and Parasitology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, SpainDepartment of Hospital Pharmacy, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, SpainDepartment of Microbiology and Parasitology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, SpainIn addition to the increase in fungal infections that has been observed in the last few decades, it has been reported that severe clinical COVID-19 can increase the risk of invasive fungal infections. The main objective of this study was to evaluate if there had been an increase in candidaemia and invasive pulmonary aspergillosis (IPA) cases since the onset of the SARS-CoV-2 pandemic. Data were retrospectively collected from April 2019 to March 2021, from patients admitted to Consorcio Hospital General Universitario de Valencia (Spain). A total of 152 candidaemia cases (56 of which were due to <i>Candida auris</i>) and 108 possible IPA cases were detected. A great increase in candidaemia cases was produced during the first and the third epidemic waves of the SARS-CoV-2 pandemic (June 2020, and January 2021, respectively), while an increase in IPA cases was produced during the third wave. The 28-day mortality rates in patients affected by candidaemia and IPA increased in 2020 and 2021. <i>C. auris</i> has displaced the other <i>Candida</i> species, becoming the most isolated <i>Candida</i> species in blood cultures since the onset of the SARS-CoV-2 pandemic. Antifungal consumption increased in 2020 when compared to 2019, especially echinocandins, voriconazole and isavuconazole.https://www.mdpi.com/2309-608X/7/6/440COVID-19IFIcandidaemiaaspergillosisantifungalsisavuconazole |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juan Vicente Mulet Bayona Nuria Tormo Palop Carme Salvador García Begoña Fuster Escrivá Mercedes Chanzá Aviñó Pilar Ortega García Concepción Gimeno Cardona |
spellingShingle |
Juan Vicente Mulet Bayona Nuria Tormo Palop Carme Salvador García Begoña Fuster Escrivá Mercedes Chanzá Aviñó Pilar Ortega García Concepción Gimeno Cardona Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary Hospital Journal of Fungi COVID-19 IFI candidaemia aspergillosis antifungals isavuconazole |
author_facet |
Juan Vicente Mulet Bayona Nuria Tormo Palop Carme Salvador García Begoña Fuster Escrivá Mercedes Chanzá Aviñó Pilar Ortega García Concepción Gimeno Cardona |
author_sort |
Juan Vicente Mulet Bayona |
title |
Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary Hospital |
title_short |
Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary Hospital |
title_full |
Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary Hospital |
title_fullStr |
Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary Hospital |
title_full_unstemmed |
Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary Hospital |
title_sort |
impact of the sars-cov-2 pandemic in candidaemia, invasive aspergillosis and antifungal consumption in a tertiary hospital |
publisher |
MDPI AG |
series |
Journal of Fungi |
issn |
2309-608X |
publishDate |
2021-05-01 |
description |
In addition to the increase in fungal infections that has been observed in the last few decades, it has been reported that severe clinical COVID-19 can increase the risk of invasive fungal infections. The main objective of this study was to evaluate if there had been an increase in candidaemia and invasive pulmonary aspergillosis (IPA) cases since the onset of the SARS-CoV-2 pandemic. Data were retrospectively collected from April 2019 to March 2021, from patients admitted to Consorcio Hospital General Universitario de Valencia (Spain). A total of 152 candidaemia cases (56 of which were due to <i>Candida auris</i>) and 108 possible IPA cases were detected. A great increase in candidaemia cases was produced during the first and the third epidemic waves of the SARS-CoV-2 pandemic (June 2020, and January 2021, respectively), while an increase in IPA cases was produced during the third wave. The 28-day mortality rates in patients affected by candidaemia and IPA increased in 2020 and 2021. <i>C. auris</i> has displaced the other <i>Candida</i> species, becoming the most isolated <i>Candida</i> species in blood cultures since the onset of the SARS-CoV-2 pandemic. Antifungal consumption increased in 2020 when compared to 2019, especially echinocandins, voriconazole and isavuconazole. |
topic |
COVID-19 IFI candidaemia aspergillosis antifungals isavuconazole |
url |
https://www.mdpi.com/2309-608X/7/6/440 |
work_keys_str_mv |
AT juanvicentemuletbayona impactofthesarscov2pandemicincandidaemiainvasiveaspergillosisandantifungalconsumptioninatertiaryhospital AT nuriatormopalop impactofthesarscov2pandemicincandidaemiainvasiveaspergillosisandantifungalconsumptioninatertiaryhospital AT carmesalvadorgarcia impactofthesarscov2pandemicincandidaemiainvasiveaspergillosisandantifungalconsumptioninatertiaryhospital AT begonafusterescriva impactofthesarscov2pandemicincandidaemiainvasiveaspergillosisandantifungalconsumptioninatertiaryhospital AT mercedeschanzaavino impactofthesarscov2pandemicincandidaemiainvasiveaspergillosisandantifungalconsumptioninatertiaryhospital AT pilarortegagarcia impactofthesarscov2pandemicincandidaemiainvasiveaspergillosisandantifungalconsumptioninatertiaryhospital AT concepciongimenocardona impactofthesarscov2pandemicincandidaemiainvasiveaspergillosisandantifungalconsumptioninatertiaryhospital |
_version_ |
1721411610432503808 |