The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
Although micro(mi)RNA-based post-transcriptional regulatory mechanisms have been implicated in the assembly and modulation of synaptic connections, few miRNAs have been identified that control synapse formation. Here, authors performed an unbiased screen for novel regulators of synapse morphogenesis...
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Nature Publishing Group
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14761-8 |
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doaj-b55a3441b07e4959ac857894059e3df72021-05-11T09:19:12ZengNature Publishing GroupNature Communications2041-17232020-02-0111111310.1038/s41467-020-14761-8The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cellsElizabeth M. McNeill0Chloe Warinner1Stephen Alkins2Alicia Taylor3Hansine Heggeness4Todd F. DeLuca5Tudor A. Fulga6Dennis P. Wall7Leslie C. Griffith8David Van Vactor9Department of Cell Biology and Program in Neuroscience, Harvard Medical SchoolDepartment of Cell Biology and Program in Neuroscience, Harvard Medical SchoolDepartment of Biology and Volen National Center for Complex Systems, Brandeis UniversityDepartment of Cell Biology and Program in Neuroscience, Harvard Medical SchoolDepartment of Cell Biology and Program in Neuroscience, Harvard Medical SchoolDepartment of Cell Biology and Program in Neuroscience, Harvard Medical SchoolDepartment of Cell Biology and Program in Neuroscience, Harvard Medical SchoolDepartment of Pediatrics, Division of Systems Medicine, Stanford UniversityDepartment of Biology and Volen National Center for Complex Systems, Brandeis UniversityDepartment of Cell Biology and Program in Neuroscience, Harvard Medical SchoolAlthough micro(mi)RNA-based post-transcriptional regulatory mechanisms have been implicated in the assembly and modulation of synaptic connections, few miRNAs have been identified that control synapse formation. Here, authors performed an unbiased screen for novel regulators of synapse morphogenesis at the Drosophila larval neuromuscular junction and discovered that miR-34 inhibits Nrx-IV to influence active zone formation, whereas, postsynaptic miR-34 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals.https://doi.org/10.1038/s41467-020-14761-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Elizabeth M. McNeill Chloe Warinner Stephen Alkins Alicia Taylor Hansine Heggeness Todd F. DeLuca Tudor A. Fulga Dennis P. Wall Leslie C. Griffith David Van Vactor |
| spellingShingle |
Elizabeth M. McNeill Chloe Warinner Stephen Alkins Alicia Taylor Hansine Heggeness Todd F. DeLuca Tudor A. Fulga Dennis P. Wall Leslie C. Griffith David Van Vactor The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells Nature Communications |
| author_facet |
Elizabeth M. McNeill Chloe Warinner Stephen Alkins Alicia Taylor Hansine Heggeness Todd F. DeLuca Tudor A. Fulga Dennis P. Wall Leslie C. Griffith David Van Vactor |
| author_sort |
Elizabeth M. McNeill |
| title |
The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells |
| title_short |
The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells |
| title_full |
The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells |
| title_fullStr |
The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells |
| title_full_unstemmed |
The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells |
| title_sort |
conserved microrna mir-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-02-01 |
| description |
Although micro(mi)RNA-based post-transcriptional regulatory mechanisms have been implicated in the assembly and modulation of synaptic connections, few miRNAs have been identified that control synapse formation. Here, authors performed an unbiased screen for novel regulators of synapse morphogenesis at the Drosophila larval neuromuscular junction and discovered that miR-34 inhibits Nrx-IV to influence active zone formation, whereas, postsynaptic miR-34 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals. |
| url |
https://doi.org/10.1038/s41467-020-14761-8 |
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