Vascular endothelial growth factor −2578C/A polymorphism and colorectal cancer risk: A meta-analysis
Background: The effects of the vascular endothelial growth factor (VEGF) gene −2578C/A polymorphism on colorectal cancer (CRC) risk have been investigated in some studies; however, the results of these studies were conflicting and ambiguous. Therefore,we aimed to do a meta-analysis to investigate th...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
Series: | Journal of Research in Medical Sciences |
Subjects: | |
Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=8;spage=811;epage=817;aulast=Wang |
id |
doaj-b5609713a6c84f4083448f4002722c2a |
---|---|
record_format |
Article |
spelling |
doaj-b5609713a6c84f4083448f4002722c2a2020-11-25T01:41:54ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362015-01-0120881181710.4103/1735-1995.168406Vascular endothelial growth factor −2578C/A polymorphism and colorectal cancer risk: A meta-analysisLei WangShan JiZeneng ChengBackground: The effects of the vascular endothelial growth factor (VEGF) gene −2578C/A polymorphism on colorectal cancer (CRC) risk have been investigated in some studies; however, the results of these studies were conflicting and ambiguous. Therefore,we aimed to do a meta-analysis to investigate the association of VEGF −2578C/A polymorphisms with CRC risk from all eligible case-control studies published to date. Materials and Methods: An electronic search of the PubMed, Embase and Medline was performed. Retrieve terms were utilized as following: ("VEGF a" [MeSH Terms]) and ("polymorphism, genetic" [MeSH Terms]) and ("colorectal neoplasms" [MeSH Terms]). The association between VEGF −2578C/A polymorphisms with CRC risk was calculated with odds ratios (ORs) and their corresponding 95% of confidence intervals (CIs), and stratified analysis was also conducted with respect to ethnicity. Results: A comprehensive meta-analysis of eight studies, including 2312 cases and 2308 controls was performed in this work. Combined analysis revealed that a significant association between the VEGF −2578C/A polymorphism with CRC risk was identified in three comparison models including C allele versus A allele (OR = 0.85, 95% CI 0.75-0.97, P = 0.02), AA versus CA + CC (OR = 1.28, 95% CI 1.09-1.51, P = 0.003), and AA versus CC (OR = 0.77, 95% CI 0.64-0.93, P = 0.006). Moreover, a similar result was obtained in the subgroup analysis that comparison models of C allele versus. A allele (OR = 0.85, 95% CI 0.76-0.95, P = 0.004), AA versus CA + CC (OR = 1.31, 95% CI 1.09-1.57, P = 0.004), and AA versus CC (OR = 0.73, 95% CI 0.59-0.90, P = 0.004) was confirmed to be associated with CRC risk in Caucasian. Conclusion: It has been proved that the C allele versus A allele, AA versus CA + CC, and AA versus CC comparison models of VEGF −2578C/A polymorphism might be risk factors for CRC, but further studies with larger sample sizes are required to make a better assessment of above association.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=8;spage=811;epage=817;aulast=WangColorectal cancermeta-analysispolymorphismvascular endothelial growth factor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Wang Shan Ji Zeneng Cheng |
spellingShingle |
Lei Wang Shan Ji Zeneng Cheng Vascular endothelial growth factor −2578C/A polymorphism and colorectal cancer risk: A meta-analysis Journal of Research in Medical Sciences Colorectal cancer meta-analysis polymorphism vascular endothelial growth factor |
author_facet |
Lei Wang Shan Ji Zeneng Cheng |
author_sort |
Lei Wang |
title |
Vascular endothelial growth factor −2578C/A polymorphism and colorectal cancer risk: A meta-analysis |
title_short |
Vascular endothelial growth factor −2578C/A polymorphism and colorectal cancer risk: A meta-analysis |
title_full |
Vascular endothelial growth factor −2578C/A polymorphism and colorectal cancer risk: A meta-analysis |
title_fullStr |
Vascular endothelial growth factor −2578C/A polymorphism and colorectal cancer risk: A meta-analysis |
title_full_unstemmed |
Vascular endothelial growth factor −2578C/A polymorphism and colorectal cancer risk: A meta-analysis |
title_sort |
vascular endothelial growth factor −2578c/a polymorphism and colorectal cancer risk: a meta-analysis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2015-01-01 |
description |
Background: The effects of the vascular endothelial growth factor (VEGF) gene −2578C/A polymorphism on colorectal cancer (CRC) risk have been investigated in some studies; however, the results of these studies were conflicting and ambiguous. Therefore,we aimed to do a meta-analysis to investigate the association of VEGF −2578C/A polymorphisms with CRC risk from all eligible case-control studies published to date. Materials and Methods: An electronic search of the PubMed, Embase and Medline was performed. Retrieve terms were utilized as following: ("VEGF a" [MeSH Terms]) and ("polymorphism, genetic" [MeSH Terms]) and ("colorectal neoplasms" [MeSH Terms]). The association between VEGF −2578C/A polymorphisms with CRC risk was calculated with odds ratios (ORs) and their corresponding 95% of confidence intervals (CIs), and stratified analysis was also conducted with respect to ethnicity. Results: A comprehensive meta-analysis of eight studies, including 2312 cases and 2308 controls was performed in this work. Combined analysis revealed that a significant association between the VEGF −2578C/A polymorphism with CRC risk was identified in three comparison models including C allele versus A allele (OR = 0.85, 95% CI 0.75-0.97, P = 0.02), AA versus CA + CC (OR = 1.28, 95% CI 1.09-1.51, P = 0.003), and AA versus CC (OR = 0.77, 95% CI 0.64-0.93, P = 0.006). Moreover, a similar result was obtained in the subgroup analysis that comparison models of C allele versus. A allele (OR = 0.85, 95% CI 0.76-0.95, P = 0.004), AA versus CA + CC (OR = 1.31, 95% CI 1.09-1.57, P = 0.004), and AA versus CC (OR = 0.73, 95% CI 0.59-0.90, P = 0.004) was confirmed to be associated with CRC risk in Caucasian. Conclusion: It has been proved that the C allele versus A allele, AA versus CA + CC, and AA versus CC comparison models of VEGF −2578C/A polymorphism might be risk factors for CRC, but further studies with larger sample sizes are required to make a better assessment of above association. |
topic |
Colorectal cancer meta-analysis polymorphism vascular endothelial growth factor |
url |
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=8;spage=811;epage=817;aulast=Wang |
work_keys_str_mv |
AT leiwang vascularendothelialgrowthfactor2578capolymorphismandcolorectalcancerriskametaanalysis AT shanji vascularendothelialgrowthfactor2578capolymorphismandcolorectalcancerriskametaanalysis AT zenengcheng vascularendothelialgrowthfactor2578capolymorphismandcolorectalcancerriskametaanalysis |
_version_ |
1725038962622332928 |