Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells.
Alterations in DNA damage response and repair have been observed in Huntington's disease (HD). We generated induced pluripotent stem cells (iPSC) from primary dermal fibroblasts of 5 patients with HD and 5 control subjects. A significant fraction of the HD iPSC lines had genomic abnormalities a...
Main Authors: | Andrew M Tidball, M Diana Neely, Reed Chamberlin, Asad A Aboud, Kevin K Kumar, Bingying Han, Miles R Bryan, Michael Aschner, Kevin C Ess, Aaron B Bowman |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4794230?pdf=render |
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