Rapamycin Nano-Micelle Ophthalmic Solution Reduces Corneal Allograft Rejection by Potentiating Myeloid-Derived Suppressor Cells' Function

Rapamycin Nano-Micelle Ophthalmic Solution Reduces Corneal Allograft Rejection by Potentiating Myeloid-Derived Suppressor Cells' Function

Allograft rejection is the major cause of corneal allograft failure. Rapamycin (RAPA) has been reported as an effective and novel immunosuppressive agent for patients undergoing corneal transplantation. However, its high water insolubility and low bioavailability have strongly constrained its clinic...

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Bibliographic Details
Main Authors: Chao Wei, Yuexin Wang, Li Ma, Xin Wang, Hao Chi, Sai Zhang, Ting Liu, Zhiyuan Li, Demeng Xiang, Yanling Dong, Xianggen Wu, Weiyun Shi, Hua Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
rapamycin
corneal allograft rejection
myeloid-derived suppressor cells
immunosuppression
iNOS
Arg-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02283/full

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