Insight into the Structural Determinants of Imidazole Scaffold-Based Derivatives as TNF-α Release Inhibitors by in Silico Explorations

Insight into the Structural Determinants of Imidazole Scaffold-Based Derivatives as TNF-α Release Inhibitors by in Silico Explorations

Presently, 151 widely-diverse pyridinylimidazole-based compounds that show inhibitory activities at the TNF-α release were investigated. By using the distance comparison technique (DISCOtech), comparative molecular field analysis (CoMFA), and comparative molecular similarity index analysis (CoMSIA)...

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Bibliographic Details
Main Authors:	Yuan Wang, Mingwei Wu, Chunzhi Ai, Yonghua Wang
Format:	Article
Language:	English
Published:	MDPI AG 2015-08-01
Series:	International Journal of Molecular Sciences
Subjects:	imidazoles TNF-α inhibitor 3D-QSAR CoMFA CoMSIA DISCOtech pharmacophore
Online Access:	http://www.mdpi.com/1422-0067/16/9/20118

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