Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach
Renal tumors comprise approximately 7% of all malignant pediatric tumors. This is a highly heterogeneous group of tumors, each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore p...
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doaj-b593f3255a934511a1ec7f4520ec60fc2020-11-25T01:53:43ZengMDPI AGCancers2072-66942020-03-0112372910.3390/cancers12030729cancers12030729Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic ApproachAriadne H.A.G. Ooms0Gordan M. Vujanić1Ellen D’Hooghe2Paola Collini3Aurore L’Herminé-Coulomb4Christian Vokuhl5Norbert Graf6Marry M. van den Heuvel-Eibrink7Ronald R. de Krijger8Princess Máxima Center for pediatric oncology, 3584 CS Utrecht, The NetherlandsDepartment of Pathology, Sidra Medicine, Doha 0000, QatarDepartment of Pathology, Oslo University Hospital, Rikshospitalet, 0372 Oslo, NorwayDepartment of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalySorbonne Université, Department of Pathology, Hôpital Armand Trousseau, Hopitaux Universitaires Est Parisien, 75012 Paris, FranceSection of Pediatric Pathology, Department of Pathology, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Pediatric Oncology & Hematology, Saarland University, D-66421 Homburg, GermanyPrincess Máxima Center for pediatric oncology, 3584 CS Utrecht, The NetherlandsPrincess Máxima Center for pediatric oncology, 3584 CS Utrecht, The NetherlandsRenal tumors comprise approximately 7% of all malignant pediatric tumors. This is a highly heterogeneous group of tumors, each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. While each tumor shows different histologic features, they do have considerable overlap in cell type and histologic pattern, making the diagnosis difficult to establish, if based on routine histology alone. To this end, ancillary techniques, such as immunohistochemistry and molecular analysis, can be of great importance for the correct diagnosis, resulting in appropriate treatment. To use ancillary techniques cost-effectively, we propose a pattern-based approach and provide recommendations to aid in deciding which panel of antibodies, supplemented by molecular characterization of a subset of genes, are required.https://www.mdpi.com/2072-6694/12/3/729pediatriconcologyrenal tumorsimmunohistochemistrymolecular analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ariadne H.A.G. Ooms Gordan M. Vujanić Ellen D’Hooghe Paola Collini Aurore L’Herminé-Coulomb Christian Vokuhl Norbert Graf Marry M. van den Heuvel-Eibrink Ronald R. de Krijger |
spellingShingle |
Ariadne H.A.G. Ooms Gordan M. Vujanić Ellen D’Hooghe Paola Collini Aurore L’Herminé-Coulomb Christian Vokuhl Norbert Graf Marry M. van den Heuvel-Eibrink Ronald R. de Krijger Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach Cancers pediatric oncology renal tumors immunohistochemistry molecular analysis |
author_facet |
Ariadne H.A.G. Ooms Gordan M. Vujanić Ellen D’Hooghe Paola Collini Aurore L’Herminé-Coulomb Christian Vokuhl Norbert Graf Marry M. van den Heuvel-Eibrink Ronald R. de Krijger |
author_sort |
Ariadne H.A.G. Ooms |
title |
Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach |
title_short |
Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach |
title_full |
Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach |
title_fullStr |
Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach |
title_full_unstemmed |
Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach |
title_sort |
renal tumors of childhood—a histopathologic pattern-based diagnostic approach |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-03-01 |
description |
Renal tumors comprise approximately 7% of all malignant pediatric tumors. This is a highly heterogeneous group of tumors, each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. While each tumor shows different histologic features, they do have considerable overlap in cell type and histologic pattern, making the diagnosis difficult to establish, if based on routine histology alone. To this end, ancillary techniques, such as immunohistochemistry and molecular analysis, can be of great importance for the correct diagnosis, resulting in appropriate treatment. To use ancillary techniques cost-effectively, we propose a pattern-based approach and provide recommendations to aid in deciding which panel of antibodies, supplemented by molecular characterization of a subset of genes, are required. |
topic |
pediatric oncology renal tumors immunohistochemistry molecular analysis |
url |
https://www.mdpi.com/2072-6694/12/3/729 |
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