Tea polyphenol decreased growth and invasion in human ovarian cancer cells
Tea polyphenols (TP) are functional substances present in tea, which is one of the most promising preventive agents for cancer. This study was carried out to analyze the effects of TP on the ovarian cancer cells and possible mechanisms involved. TP led to inhibition of cell growth in a time- and dos...
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2016-12-01
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Series: | European Journal of Inflammation |
Online Access: | https://doi.org/10.1177/1721727X16674480 |
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doaj-b59f5a3d03ce425ab839a0873bc4107c2020-11-25T03:08:35ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2016-12-011410.1177/1721727X16674480Tea polyphenol decreased growth and invasion in human ovarian cancer cellsQin Huang0Ting Du1Qiu-Xia Qu2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, PR ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, PR ChinaClinical Immunology Institute, The First Affiliated Hospital of Soochow University, Suzhou, PR ChinaTea polyphenols (TP) are functional substances present in tea, which is one of the most promising preventive agents for cancer. This study was carried out to analyze the effects of TP on the ovarian cancer cells and possible mechanisms involved. TP led to inhibition of cell growth in a time- and dose-dependent manner, and promoted entry into the apoptosis-phase of the cell cycle. TP also decreased the invasion of ovarian cancer cells in vitro. In addition, TP treatment upregulated the mRNA expressions rate of Bax/Bcl-2 and downregulated Cyclin D and MMP2 mRNA expressions. Taken together, our data highlight that TP could be a potential therapeutic strategy for ovarian cancer. These findings also suggested that oncogens are involved in the anti-cancer effects of TP.https://doi.org/10.1177/1721727X16674480 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qin Huang Ting Du Qiu-Xia Qu |
spellingShingle |
Qin Huang Ting Du Qiu-Xia Qu Tea polyphenol decreased growth and invasion in human ovarian cancer cells European Journal of Inflammation |
author_facet |
Qin Huang Ting Du Qiu-Xia Qu |
author_sort |
Qin Huang |
title |
Tea polyphenol decreased growth and invasion in human ovarian cancer cells |
title_short |
Tea polyphenol decreased growth and invasion in human ovarian cancer cells |
title_full |
Tea polyphenol decreased growth and invasion in human ovarian cancer cells |
title_fullStr |
Tea polyphenol decreased growth and invasion in human ovarian cancer cells |
title_full_unstemmed |
Tea polyphenol decreased growth and invasion in human ovarian cancer cells |
title_sort |
tea polyphenol decreased growth and invasion in human ovarian cancer cells |
publisher |
SAGE Publishing |
series |
European Journal of Inflammation |
issn |
1721-727X |
publishDate |
2016-12-01 |
description |
Tea polyphenols (TP) are functional substances present in tea, which is one of the most promising preventive agents for cancer. This study was carried out to analyze the effects of TP on the ovarian cancer cells and possible mechanisms involved. TP led to inhibition of cell growth in a time- and dose-dependent manner, and promoted entry into the apoptosis-phase of the cell cycle. TP also decreased the invasion of ovarian cancer cells in vitro. In addition, TP treatment upregulated the mRNA expressions rate of Bax/Bcl-2 and downregulated Cyclin D and MMP2 mRNA expressions. Taken together, our data highlight that TP could be a potential therapeutic strategy for ovarian cancer. These findings also suggested that oncogens are involved in the anti-cancer effects of TP. |
url |
https://doi.org/10.1177/1721727X16674480 |
work_keys_str_mv |
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_version_ |
1724665532410494976 |