Tea polyphenol decreased growth and invasion in human ovarian cancer cells

Tea polyphenol decreased growth and invasion in human ovarian cancer cells

Tea polyphenols (TP) are functional substances present in tea, which is one of the most promising preventive agents for cancer. This study was carried out to analyze the effects of TP on the ovarian cancer cells and possible mechanisms involved. TP led to inhibition of cell growth in a time- and dos...

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Main Authors: Qin Huang, Ting Du, Qiu-Xia Qu
Format: Article
Language:English
Published: SAGE Publishing 2016-12-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X16674480
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spelling doaj-b59f5a3d03ce425ab839a0873bc4107c2020-11-25T03:08:35ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2016-12-011410.1177/1721727X16674480Tea polyphenol decreased growth and invasion in human ovarian cancer cellsQin Huang0Ting Du1Qiu-Xia Qu2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, PR ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, PR ChinaClinical Immunology Institute, The First Affiliated Hospital of Soochow University, Suzhou, PR ChinaTea polyphenols (TP) are functional substances present in tea, which is one of the most promising preventive agents for cancer. This study was carried out to analyze the effects of TP on the ovarian cancer cells and possible mechanisms involved. TP led to inhibition of cell growth in a time- and dose-dependent manner, and promoted entry into the apoptosis-phase of the cell cycle. TP also decreased the invasion of ovarian cancer cells in vitro. In addition, TP treatment upregulated the mRNA expressions rate of Bax/Bcl-2 and downregulated Cyclin D and MMP2 mRNA expressions. Taken together, our data highlight that TP could be a potential therapeutic strategy for ovarian cancer. These findings also suggested that oncogens are involved in the anti-cancer effects of TP.https://doi.org/10.1177/1721727X16674480
collection DOAJ
language English
format Article
sources DOAJ
author Qin Huang
Ting Du
Qiu-Xia Qu
spellingShingle Qin Huang
Ting Du
Qiu-Xia Qu
Tea polyphenol decreased growth and invasion in human ovarian cancer cells
European Journal of Inflammation
author_facet Qin Huang
Ting Du
Qiu-Xia Qu
author_sort Qin Huang
title Tea polyphenol decreased growth and invasion in human ovarian cancer cells
title_short Tea polyphenol decreased growth and invasion in human ovarian cancer cells
title_full Tea polyphenol decreased growth and invasion in human ovarian cancer cells
title_fullStr Tea polyphenol decreased growth and invasion in human ovarian cancer cells
title_full_unstemmed Tea polyphenol decreased growth and invasion in human ovarian cancer cells
title_sort tea polyphenol decreased growth and invasion in human ovarian cancer cells
publisher SAGE Publishing
series European Journal of Inflammation
issn 1721-727X
publishDate 2016-12-01
description Tea polyphenols (TP) are functional substances present in tea, which is one of the most promising preventive agents for cancer. This study was carried out to analyze the effects of TP on the ovarian cancer cells and possible mechanisms involved. TP led to inhibition of cell growth in a time- and dose-dependent manner, and promoted entry into the apoptosis-phase of the cell cycle. TP also decreased the invasion of ovarian cancer cells in vitro. In addition, TP treatment upregulated the mRNA expressions rate of Bax/Bcl-2 and downregulated Cyclin D and MMP2 mRNA expressions. Taken together, our data highlight that TP could be a potential therapeutic strategy for ovarian cancer. These findings also suggested that oncogens are involved in the anti-cancer effects of TP.
url https://doi.org/10.1177/1721727X16674480
work_keys_str_mv AT qinhuang teapolyphenoldecreasedgrowthandinvasioninhumanovariancancercells
AT tingdu teapolyphenoldecreasedgrowthandinvasioninhumanovariancancercells
AT qiuxiaqu teapolyphenoldecreasedgrowthandinvasioninhumanovariancancercells
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