Dual-energy X-ray absorptiometry assessment of postmenopausal women with vertebral fragility fracture and its relationship with serum bone turnover and bone metabolism indexes

• Main Author: Wei Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-11-01
• Series: Journal of Hainan Medical University
• Subjects: Postmenopausal osteoporosis; Bone mineral density; Vertebral fragility fracture; Bone turnover; Bone metabolism
• Online Access: http://www.hnykdxxb.com/PDF/201621/8.pdf

Objective: To study the relationship between dual-energy X-ray bone mass density measurement results of postmenopausal women with vertebral fragility fracture and the serum bone turnover as well as bone metabolism indexes. Methods: A total of 158 postmenopausal women who received DXA tests in our hospital between April 2012 and December 2015 were selected, were divided into osteoporosis group, osteopenia group and normal bone mass group according to the bone mineral density measurement results, and were divided into no vertebral fracture group, thoracic vertebral fracture group, lumbar vertebral fracture group and thoracolumbar vertebral fracture group according to the thoracolumbar vertebral anterioposterior and lateral film results, and serum was collected to determine bone turnover and bone metabolism indexes. Results: Femoral neck, hip and lumbar vertebra L1-4 bone mineral density of subjects with thoracic vertebral fracture and thoracolumbar vertebral fracture were significantly lower than those of the subjects without vertebral fracture, and femoral neck, hip and lumbar vertebra L1-4 bone mineral density of subjects with lumbar vertebral fracture were not significantly different from those of the subjects without vertebral fracture; serum PINP, ICTP, CTX, TRACP-5b, MMP13, OPG and OPN content of osteoporosis group and osteopenia group were significantly higher than those of normal bone mass group while 25(OH)D, BGP and ON content were significantly lower than those of normal bone mass group; serum PINP, ICTP, CTX, TRACP-5b, MMP13, OPG and OPN content of osteoporosis group were significantly higher than those of osteopenia group while 25(OH)D, BGP and ON content were significantly lower than those of osteopenia group. Conclusions: Dual-energy X-ray bone densitometry has clear prediction value for postmenopausal women with thoracic vertebral fragility fracture and thoracolumbar vertebral fragility fracture, and is closely related to the changes of bone turnover and bone metabolism.