Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility
We aimed to estimate the seroprevalence and the prevalence of coeliac disease (CD) in women with reproductive problems. A systematic review of English published articles until June 2019 was performed in PubMed and Scopus using the terms: (infertility and (coeliac disease OR gluten) OR (miscarriage a...
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doaj-b5a9d7376d424a94a2675b95e0da936d2020-11-24T21:34:18ZengMDPI AGNutrients2072-66432019-08-01118195010.3390/nu11081950nu11081950Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with InfertilityMercedes Castaño0Rubén Gómez-Gordo1David Cuevas2Concepción Núñez3Laboratorio de investigación en Genética de enfermedades complejas, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, SpainLaboratorio de Biología Vascular y Microbiota, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, SpainLaboratorio de investigación en Genética de enfermedades complejas, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, SpainLaboratorio de investigación en Genética de enfermedades complejas, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, SpainWe aimed to estimate the seroprevalence and the prevalence of coeliac disease (CD) in women with reproductive problems. A systematic review of English published articles until June 2019 was performed in PubMed and Scopus using the terms: (infertility and (coeliac disease OR gluten) OR (miscarriage and (coeliac disease OR gluten) OR (abortion and (coeliac disease OR gluten). All articles showing numerical data of anti-transglutaminase type 2 or anti-endomisium antibodies, or intestinal biopsy information were included. The study group comprised women with overall infertility, unexplained infertility, or recurrent spontaneous abortions. Two authors independently performed data extraction using a predefined data sheet. The initial search yielded 310 articles, and 23 were selected for data extraction. After meta-analysis, the pooled seroprevalence was very similar for overall and unexplained infertility, with a pooled proportion of around 1.3%−1.6%. This implies three times higher odds of having CD in infertility when compared to controls. The pooled prevalence could not be accurately calculated due to the small sample sizes. Further studies with increased sample sizes are necessary before giving specific recommendations for CD screening in women with reproductive problems, but current data seem to support a higher risk of CD in these women.https://www.mdpi.com/2072-6643/11/8/1950coeliac diseasereproductive disordersinfertilityrecurrent abortion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mercedes Castaño Rubén Gómez-Gordo David Cuevas Concepción Núñez |
spellingShingle |
Mercedes Castaño Rubén Gómez-Gordo David Cuevas Concepción Núñez Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility Nutrients coeliac disease reproductive disorders infertility recurrent abortion |
author_facet |
Mercedes Castaño Rubén Gómez-Gordo David Cuevas Concepción Núñez |
author_sort |
Mercedes Castaño |
title |
Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility |
title_short |
Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility |
title_full |
Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility |
title_fullStr |
Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility |
title_full_unstemmed |
Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility |
title_sort |
systematic review and meta-analysis of prevalence of coeliac disease in women with infertility |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-08-01 |
description |
We aimed to estimate the seroprevalence and the prevalence of coeliac disease (CD) in women with reproductive problems. A systematic review of English published articles until June 2019 was performed in PubMed and Scopus using the terms: (infertility and (coeliac disease OR gluten) OR (miscarriage and (coeliac disease OR gluten) OR (abortion and (coeliac disease OR gluten). All articles showing numerical data of anti-transglutaminase type 2 or anti-endomisium antibodies, or intestinal biopsy information were included. The study group comprised women with overall infertility, unexplained infertility, or recurrent spontaneous abortions. Two authors independently performed data extraction using a predefined data sheet. The initial search yielded 310 articles, and 23 were selected for data extraction. After meta-analysis, the pooled seroprevalence was very similar for overall and unexplained infertility, with a pooled proportion of around 1.3%−1.6%. This implies three times higher odds of having CD in infertility when compared to controls. The pooled prevalence could not be accurately calculated due to the small sample sizes. Further studies with increased sample sizes are necessary before giving specific recommendations for CD screening in women with reproductive problems, but current data seem to support a higher risk of CD in these women. |
topic |
coeliac disease reproductive disorders infertility recurrent abortion |
url |
https://www.mdpi.com/2072-6643/11/8/1950 |
work_keys_str_mv |
AT mercedescastano systematicreviewandmetaanalysisofprevalenceofcoeliacdiseaseinwomenwithinfertility AT rubengomezgordo systematicreviewandmetaanalysisofprevalenceofcoeliacdiseaseinwomenwithinfertility AT davidcuevas systematicreviewandmetaanalysisofprevalenceofcoeliacdiseaseinwomenwithinfertility AT concepcionnunez systematicreviewandmetaanalysisofprevalenceofcoeliacdiseaseinwomenwithinfertility |
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1725950036220575744 |