Next generation sequencing based assessment of the alloreactive T cell receptor repertoire in kidney transplant patients during rejection: a prospective cohort study

Next generation sequencing based assessment of the alloreactive T cell receptor repertoire in kidney transplant patients during rejection: a prospective cohort study

Abstract Background Kidney transplantation is the optimal treatment in end stage renal disease but the allograft survival is still hampered by immune reactions against the allograft. This process is driven by the recognition of allogenic antigens presented to T-cells and their unique T-cell receptor...

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Bibliographic Details
Main Authors: Constantin Aschauer, Kira Jelencsics, Karin Hu, Andreas Heinzel, Julia Vetter, Thomas Fraunhofer, Susanne Schaller, Stephan Winkler, Lisabeth Pimenov, Guido A. Gualdoni, Michael Eder, Alexander Kainz, Heinz Regele, Roman Reindl-Schwaighofer, Rainer Oberbauer
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Nephrology
Subjects:
T cell receptor
Alloreactivity
Kidney transplant
Rejection
Next generation sequencing
Online Access:http://link.springer.com/article/10.1186/s12882-019-1541-5

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