18-Fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis
Objectives: To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography–computed tomography (18F-FDG-PET–CT) in the diagnosis of infectious endocarditis (IE). Methods: We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of To...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-11-01
|
Series: | International Journal of Infectious Diseases |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971214015252 |
id |
doaj-b5b39aeabdd0479aa1ea0f88f66fba61 |
---|---|
record_format |
Article |
spelling |
doaj-b5b39aeabdd0479aa1ea0f88f66fba612020-11-24T22:47:15ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112014-11-0128C21922410.1016/j.ijid.2014.04.02818-Fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditisAlessandra Ricciardi0Pasquale Sordillo1Laura Ceccarelli2Gaetano Maffongelli3Giorgio Calisti4Barbara Di Pietro5Cristiana Ragano Caracciolo6Orazio Schillaci7Antonio Pellegrino8Luigi Chiariello9Massimo Andreoni10Loredana Sarmati11Clinical Infectious Diseases, Tor Vergata University, V. Montpellier 1, 00133, Rome, ItalyClinical Infectious Diseases, Tor Vergata University, V. Montpellier 1, 00133, Rome, ItalyClinical Infectious Diseases, Tor Vergata University, V. Montpellier 1, 00133, Rome, ItalyClinical Infectious Diseases, Tor Vergata University, V. Montpellier 1, 00133, Rome, ItalyDepartment of Virology, Royal Free London NHS Foundation Trust, London, UKDepartment of Biopathology and Diagnostic Imaging, Tor Vergata University, Rome, ItalyDepartment of Biopathology and Diagnostic Imaging, Tor Vergata University, Rome, ItalyDepartment of Biopathology and Diagnostic Imaging, Tor Vergata University, Rome, ItalyCardiac Surgery Unit, Tor Vergata University, Rome, ItalyCardiac Surgery Unit, Tor Vergata University, Rome, ItalyClinical Infectious Diseases, Tor Vergata University, V. Montpellier 1, 00133, Rome, ItalyClinical Infectious Diseases, Tor Vergata University, V. Montpellier 1, 00133, Rome, Italy Objectives: To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography–computed tomography (18F-FDG-PET–CT) in the diagnosis of infectious endocarditis (IE). Methods: We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of Tor Vergata University Hospital between 2009 and 2013 with a suspicion of IE. The final IE diagnosis was defined according to the modified Duke criteria, and the microbiological and diagnostic results were collected for each patient. Results: Twenty out of 27 patients had a suspected prosthetic valve endocarditis (PVE) and seven had a suspected native valve endocarditis (NVE). Twenty-five out of 27 patients (92%) had a confirmed diagnosis of IE (18/25 PVE and 7/25 NVE); 16 had a positive echocardiography evaluation and 16 had positive 18F-FDG-PET–CT findings. Echocardiography showed a higher sensitivity as a diagnostic tool for the detection of IE compared to 18F-FDG-PET–CT (80% vs. 55%). However, a greater number of PVE had positive 18F-FDG-PET–CT results compared to those with positive echocardiography findings (11/13 vs. 9/13), and overall 89% (16/18) of confirmed PVE resulted 18F-FDG-PET–CT positive. Analyzing only the cases who underwent transoesophageal echocardiography, 18F-FDG-PET–CT showed a sensitivity of 85% in PVE (vs. 69% for echocardiography and 77% for the Duke criteria). All seven patients with NVE had a positive echocardiography and negative 18F-FDG-PET–CT findings (p < 0.001). Conclusions: The results of this study further highlight the limitations of echocardiography in the diagnosis of PVE and the potential advantages of 18F-FDG-PET–CT in these cases. http://www.sciencedirect.com/science/article/pii/S120197121401525218F-FDG-PET–CTProsthetic valve endocarditisCardiac imagingInfective endocarditisEchocardiography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alessandra Ricciardi Pasquale Sordillo Laura Ceccarelli Gaetano Maffongelli Giorgio Calisti Barbara Di Pietro Cristiana Ragano Caracciolo Orazio Schillaci Antonio Pellegrino Luigi Chiariello Massimo Andreoni Loredana Sarmati |
spellingShingle |
Alessandra Ricciardi Pasquale Sordillo Laura Ceccarelli Gaetano Maffongelli Giorgio Calisti Barbara Di Pietro Cristiana Ragano Caracciolo Orazio Schillaci Antonio Pellegrino Luigi Chiariello Massimo Andreoni Loredana Sarmati 18-Fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis International Journal of Infectious Diseases 18F-FDG-PET–CT Prosthetic valve endocarditis Cardiac imaging Infective endocarditis Echocardiography |
author_facet |
Alessandra Ricciardi Pasquale Sordillo Laura Ceccarelli Gaetano Maffongelli Giorgio Calisti Barbara Di Pietro Cristiana Ragano Caracciolo Orazio Schillaci Antonio Pellegrino Luigi Chiariello Massimo Andreoni Loredana Sarmati |
author_sort |
Alessandra Ricciardi |
title |
18-Fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis |
title_short |
18-Fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis |
title_full |
18-Fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis |
title_fullStr |
18-Fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis |
title_full_unstemmed |
18-Fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis |
title_sort |
18-fluoro-2-deoxyglucose positron emission tomography–computed tomography: an additional tool in the diagnosis of prosthetic valve endocarditis |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 1878-3511 |
publishDate |
2014-11-01 |
description |
Objectives: To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography–computed tomography (18F-FDG-PET–CT) in the diagnosis of infectious endocarditis (IE).
Methods: We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of Tor Vergata University Hospital between 2009 and 2013 with a suspicion of IE. The final IE diagnosis was defined according to the modified Duke criteria, and the microbiological and diagnostic results were collected for each patient.
Results: Twenty out of 27 patients had a suspected prosthetic valve endocarditis (PVE) and seven had a suspected native valve endocarditis (NVE). Twenty-five out of 27 patients (92%) had a confirmed diagnosis of IE (18/25 PVE and 7/25 NVE); 16 had a positive echocardiography evaluation and 16 had positive 18F-FDG-PET–CT findings. Echocardiography showed a higher sensitivity as a diagnostic tool for the detection of IE compared to 18F-FDG-PET–CT (80% vs. 55%). However, a greater number of PVE had positive 18F-FDG-PET–CT results compared to those with positive echocardiography findings (11/13 vs. 9/13), and overall 89% (16/18) of confirmed PVE resulted 18F-FDG-PET–CT positive. Analyzing only the cases who underwent transoesophageal echocardiography, 18F-FDG-PET–CT showed a sensitivity of 85% in PVE (vs. 69% for echocardiography and 77% for the Duke criteria). All seven patients with NVE had a positive echocardiography and negative 18F-FDG-PET–CT findings (p < 0.001).
Conclusions: The results of this study further highlight the limitations of echocardiography in the diagnosis of PVE and the potential advantages of 18F-FDG-PET–CT in these cases.
|
topic |
18F-FDG-PET–CT Prosthetic valve endocarditis Cardiac imaging Infective endocarditis Echocardiography |
url |
http://www.sciencedirect.com/science/article/pii/S1201971214015252 |
work_keys_str_mv |
AT alessandraricciardi 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT pasqualesordillo 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT lauraceccarelli 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT gaetanomaffongelli 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT giorgiocalisti 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT barbaradipietro 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT cristianaraganocaracciolo 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT orazioschillaci 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT antoniopellegrino 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT luigichiariello 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT massimoandreoni 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis AT loredanasarmati 18fluoro2deoxyglucosepositronemissiontomographycomputedtomographyanadditionaltoolinthediagnosisofprostheticvalveendocarditis |
_version_ |
1725682288744726528 |